脑梗死颈动脉粥样硬化患者血清MMP-9水平的测定及临床意义  

Relationship between serum MMP-9 and carotid atherosclerosis in patients with cerebral infarction

作　　者：郝清华[1] 孙美华 闵敏[1] 宋士洪[2] 

机构地区：[1]济宁医学院附属滕州市中心人民医院神经内科,山东省277500 [2]济宁医学院附属滕州市中心人民医院检验科,山东省277500

出　　处：《中华临床医师杂志（电子版）》2009年第4期43-45,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：滕州市科技发展基金资助项目(2008037)

摘　　要：目的探讨脑梗死患者颈动脉粥样硬化与血清基质金属蛋白酶-9(MMP-9)水平的关系。方法应用彩色Doppler超声诊断仪检测颈动脉内膜中层厚度(IMT),以及有无斑块形成及斑块形态。应用双抗体夹心酶联免疫吸附法(ELISA)检测100例脑梗死患者的血清MMP-9水平,并进行相关分析。结果不稳定斑块组空腹血清MMP-9浓度为(549.93±153.12)ng/ml,高于稳定斑块组和无斑块组的(281.45±120.34)ng/ml和(87.36±23.62)ng/ml,差异具有统计学意义(P<0.01)。结论血清MMP-9水平的升高,可成为颈动脉粥样硬化斑块易损性的独立预测因素。血清MMP-9水平增高与颈动脉粥样硬化斑块不稳定性密切相关。Objective To investigate the relationship between serum MMP-9 levels and carotid atherosclerosis in patients with cerebral infarction. Methods All carotid arteries of the patients were examined with color Doppler ultrasound and intima-media thickness （IMT） and the shape of plaques were measured. The levels of serum MMP-9 in Patients with Cerebral infarction （n = 100 ） were measured respectively. Results The levels of serum MMP-9 in unstable-plaque group was（549. 93 ± 153.12）ng/ml, It was significantly higher than（281.45 ± 120. 34） ng/ml and （ 87.36 ± 23.62 ） ng/ml in the stable-plaque group and the non-plaque group （P 〈 0. 01 ） ,respectively. Conclusions The elevation of the serum MMP-9 levels may be the independently prediction factors for the wearing of the carotid atherosclerotic plaques. It is closely associated with the occurrence and development of ischemic stroke.

关 键 词：脑梗死 颈动脉 动脉粥样硬化 基质金属蛋白酶9 

分 类 号：R743.3[医药卫生—神经病学与精神病学]