p16基因缺失与鼻咽癌预后的相关性  

Correlation Between Loss of p16 Gene and Prognosis in Nasopharnygeal Carcinoma

作　　者：何侠[1] 宋丹[1] 陈森清[1] 李金田[1] 郑必惠[1] 

机构地区：[1]江苏省肿瘤医院,江苏南京210009

出　　处：《肿瘤学杂志》2009年第4期281-283,共3页Journal of Chinese Oncology

基　　金：江苏省自然科学基金资助课题(BK2002136)

摘　　要：[目的]探讨p16基因缺失在鼻咽癌中的临床意义。[方法]采用多重PCR分析法,对157例鼻咽癌标本p16基因突变情况进行检测。[结果]鼻咽癌组织中p16基因第2外显子的缺失率为35.0%(55/157)。p16基因第2外显子的缺失与鼻咽癌的临床分期、性别、年龄无显著性相关,但生存期<3年者的p16基因第2外显子的缺失率高于生存期>3年者(69.57%vs.29.10%,χ2=14.12,P=0.000)。[结论]p16基因第2外显子可能与鼻咽癌的发生、发展和预后有关。[Purpose] To investigate the significance of p16 gene loss in nasopharyngeal carcinoma（NPC）. [Methods] p16 gene loss in 157 cases with NPC was detected by multiplex polymerase chain reaction（PCR）. [Results] Loss rate of p16 gene exon 2 in nasopharyngeal carcinoma tissue was 35.0%（55/157）. Loss of p16 exon 2 did not correlate to stage, gender and age in NPC, but the loss of p16 exon 1 in cases with survival〈3years was higher than that in 〉3years （69.57% vs. 29.10%,χ^2=4.120,P=0.000）. [Conclusion] Loss of p16 gene exon 2 might correlate to carcinogenesis and progress in nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 基因 p16 预后 多重PCR 

分 类 号：R739.63[医药卫生—肿瘤]