法莫替丁联合氯波比利治疗功能性消化不良的临床研究  

The Clinical Research of Famotidine Combine with Clebopride Malate in Treating Functional Dyspepsia

作　　者：陈民 王朝松 

机构地区：[1]河南省漯河市第二人民医院,漯河462000

出　　处：《中国医药导刊》2009年第3期435-436,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:评价法莫替丁联合氯波比利治疗功能性消化不良(FD)的疗效。方法:将2006年1月～2008年12月在我院消化内科门诊就诊的311例FD患者随机分为两组,口服法莫替丁和氯波比利170例(观察组),口服奥美拉唑和氯波比利共141例(对照组)。疗程均为2周。观察两组患者胃部烧灼感、餐后饱胀、上腹痛及嗳气等症状改善程度。结果:两组治疗前后胃部烧灼感、上腹痛症状分级评分明显下降的差异均有统计学意义(p<0.01);餐后饱胀、嗳气症状分级评分下降的差异有统计学意义(p<0.05);上述症状评分治疗后两组比较,差异均无统计学意义,(15>0.05)。结论:法莫替丁和氯波比利联合治疗FD疗效肯定,与奥美拉唑和氯波比利联合用药效果相近,而且药物不良反应少,费用低,可作为治疗FD首选药。Objective： To estimate the efficacy of famotidine combined with ctebopride malate in treating Functional Dyspepsia （FD）. Methods： 311 FD cases in digestive medical clinic between Jan.2006 and Dec.2008 were randomly divided into two groups. The observation group with 170 cases took famotidine and clebopride malate and the contrast group with 141 cases took omeprazole and clebopride malate. All cases took medicine for 2 weeks. The relief of symptoms such like gastric burn, postprandial dropsical, upper abdominal pain and belching were observed. Results： The degree of gastric burn and upper abdominal pain lowered after therapy （P〈0.01） and postprandial dropsical, belching lowered too （P〈0.05）. But no difference were shown between the two groups after therapy （P〉0.05）. Conclusions： The efficacy of famotidine combine with clebopride malate in treating functional dyspepsia was confirmed. They can be chosen as the first line drugs because of less adverse effcct, lower expense and similar effectiveness compared with omeprazole and clebopride malate.

关 键 词：功能性消化不良 法莫替丁 奥美拉唑 氯波比利 治疗 

分 类 号：R57[医药卫生—消化系统]