检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:刘畅[1]
出 处:《中国医药导刊》2009年第4期639-641,共3页Chinese Journal of Medicinal Guide
摘 要:目的:探讨红细胞生成素诱导的肝细胞受体EphB4及其配体EphrinB2 mRNA在子宫内膜癌组织中的表达及意义。方法:采用逆转录PCR(RT-RCR)法检测33例子宫内膜癌和10例正常子宫内膜组织中EphB4、EphrinB mRNA的表达率及相对含量,并分析二者与子宫内膜癌临床病理特征的关系。结果:(1)EphB4 mRNA在子宫内膜癌组的表达率和相对含量均高于正常子宫内膜组(P<0.05,P<0.05)。EphrinB2mRNA在于宫内膜癌组的表达率和相对含量也均高于正常子宫内膜组(P<0.05,P<0.01)。(2)EphB4、EphrinB2mRNA的表达与子宫内膜癌手术病理分期、组织学分级有密切关系(P<0.05)。二者表达与子宫内膜癌不同组织学类型,肌层浸润程度以及有无淋巴结转移无关(P>0.05)。结论:EphB4和EphrinB2的异常表达与子宫内膜癌发生、进展以及恶性程度有关,二者表达趋势呈现一致性,检测EphB4/EphririB2有助于判断子宫内膜癌预后。Objective:To study the differential expression of EphB4,EphrinB2 mRNA in endometrial cancer,and to anylaze their significance. Methods:RT-PCR method was used to detect the expression of EphB4,EphrinB2 mRNA in 33 cases of endometrial cancer and 10 cases of nomal endometrial tissues. Results : ( 1 ) The expression rates and relative content of EphB4 mRNA in endometrial carcinoma were higher than that in normal endometrial tissues significantly. ( P 〈 0. 05, P 〈 0. 05 ). The expression rates and relative content of EphrinB2 mRNA in endometrial carcinoma were higher than that in normal endometrial tissues significantly. ( P 〈 0. 05, P 〈 0. 01 ). ( 2 ) The expressions of EphB4 , EphrinB2 mRNA were correlated with their stage and histological grade( P 〈 0.05 ). But their expressions had no relationship with the histological type,depth of myometrium invasion and lymphatic metastasis of endometrial carcinoma( P 〉 0. 05 ). Conclusions: Overexpression of EphB4 and EphrinB2 may play an important role in the oncogenesis, progression and malignant degree of endometfial cancer. The mRNA expressions of EphB4 and EphrinB2 in endometrial carcinoma were coincident. Detection of EphB4 and EphrinB2 expression might be helpful to predict prognosis of patients with endometrial carcinoma.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.28