山豆根中毒致苍白球损害和全身扭转肌张力障碍2例  

Globus pallidus lesion and generalized torsion dystonia due to Shandougen poisoning in two patients

作　　者：黄光[1] 唐煜[1] 王俊芳[1] 杜铁英[1] 

机构地区：[1]首都医科大学附属复兴医院神经内科,北京100038

出　　处：《药物不良反应杂志》2009年第2期111-113,共3页Adverse Drug Reactions Journal

摘　　要：山豆根为豆科植物越南槐的干燥根及根茎,含有苦参碱和氧化苦参碱等。山豆根具有抗炎、解热、抗菌及抗病毒作用,常用量为3～6g/d,剂量>10g可致中毒。主要中毒症状为恶心、呕吐、腹痛、腹泻、四肢颤抖、抽搐、昏迷、心搏加速、呼吸抑制、血压下降。患者可因呼吸衰竭、肺水肿死亡。本文报告2例患儿服用山豆根中毒致苍白球损害和全身扭转肌张力障碍2例。例1,12岁男性患儿,因肝炎每日用山豆根20g制成煎剂分3次服用治疗。例2,4岁男性患儿,因感冒每日用山豆根5g制成煎剂服用治疗。之后,2例患儿均出现苍白球损害和全身扭转肌张力障碍,停用山豆根,经氯硝西泮口服治疗后,症状均明显减轻。Shandougen is dried root and rhizome of Sophora tonkinensis Gapnep, which contains matrine and oxymatrine, and so 6n. Shandougen has anti-inflammatory, antipyretic, antibacterial and antiviral effects, and its common dosage is 3 ～ 6 g daily. The dosage 〉 10 g may cause toxication. The main symptoms of toxication include nausea, vomiting, abdominal pain, diarrhea, tremor of extremities, convulsion, coma, tachycardia, respiratory depression, decreased blood pressure. Death may result from respiratory failure and pulmonary edema. This paper reports globus pallidus lesion and generalized torsion dystonia due to Shandougen poisoning in two patients. Patient 1, a 12-year-old boy, received from Shandougen 20 g/day which was prepared to a decoction and was divided into three equal doses for hepatitis. Patient 2, a 4-year-old boy, received from Shandougen 5 g/day which was prepared to a decoction for a cold. Later, both patients developed globus pallidus lesion and generalized torsion dystonia. Shandougen was discontinued and oral clonazepam was given, then their symptoms were markedly relieved.

关 键 词：山豆根 中毒 苍白球损害 全身扭转肌张力障碍 

分 类 号：R725.9[医药卫生—儿科]