多奈哌齐联合康复治疗早期脑卒中偏瘫的临床研究  

Donepezil and rehabilitation for stroke hemiplegia patients

作　　者：袁淑娟[1] 席永兵[1] 梁英[1] 薛燕萍[1] 

机构地区：[1]山西医科大学第一医院康复科,030001

出　　处：《中国医药》2009年第5期368-369,共2页China Medicine

摘　　要：目的探讨多奈哌齐联合康复治疗对早期脑卒中偏瘫患者运动功能及认知的影响。方法40例发病3—14d的脑卒中偏瘫患者按照由神经内科转入康复科先后顺序分为两组，单号18例为对照组给予常规康复训练；双号22例为研究组在进行常规康复训练的同时，给予多奈哌齐5mg，1次／d口服，分别在转入康复科时和1个月、2个月后采用简式Fugl-Meyer运动量表（FMA）、Barthel指数评分法及简易智能精神状态检查量表（MMSE）评定疗效。结果早期康复后患者的运动功能和日常生活能力及认知均明显提高，差别有统计学意义（均P〈0．05），而研究组较对照组的FMA、Barthel指数及MMSE评分改善差异有统计学意义（均P〈0．01）。研究组治疗前后生命体征、血常规、肝功能、血脂、血糖、心电图等指标治疗前后均无明显变化（P〉0．05）、无严重不良反应。结论早期脑卒中偏瘫患者多奈哌齐联合康复治疗可明显改善患者的认知、运动及日常生活能力，且安全性好。Objective To study the effect of early Donepezil and rehabilitation on motor function and cognize in stroke hemiplegia patients. Methods Forty stroke patients were enrolled into two groups stochastically, 18 collator received general training and 22 curers received rehabilitation training and taken Donepezil 5 mg/d. The FMA, Barthel and MMSE index were administered to evaluate curative effect during first visit to a doctor and following 1 and 2 months. Results After rehabilitation the motor function, daily life abilities and cognize were improved（ P 〈0.01 ）. The treatment group was superior to the control group, showing significant differences before and after treatment （P 〈 0.01 ）. Conclusion Early Donepezil and rehabilitation can improve the cognize, motor function and ADL of stroke hemiplegia patients.

关 键 词：脑卒中 多奈哌齐 康复 偏瘫 

分 类 号：R743.34[医药卫生—神经病学与精神病学]