转移抑制基因Kai1在肺癌中的表达及临床意义  

Expression and clinical significance of metastasis suppressor gene Kai1 in lung cancer

作　　者：葛彤 秦昊 徐秀杰 张大鹏 

机构地区：[1]哈尔滨市第二医院内科,黑龙江哈尔滨150056

出　　处：《中国医药导报》2009年第13期19-20,共2页China Medical Herald

摘　　要：目的:检测转移抑制基因Kai1的蛋白表达,探讨其与肺癌生物学行为的关系。方法:采用免疫组化SP法分别测定53例肺癌及17例正常肺脏新鲜冰冻组织中Kai1蛋白的表达。结果:53例肺癌中19例(36%)Kai1蛋白表达阳性,与正常肺脏(82%)相比,差异有非常显著性(P<0.01)。早期肺癌Kai1蛋白表达率明显高于中、晚期肺癌(P<0.05)。癌细胞分化程度Ⅰ、Ⅱ级肺癌Kai1表达率明显高于晚期Ⅲ、Ⅳ级(P<0.05)。结论:Kai1蛋白表达下降可能预示着转移,且与肺癌恶性程度有关,可成为判断预后的因素之一。Objective： To explore the expression and clinical significance of metastasis suppressor gene Kail in lung cancer. Methods： The expression of Kail protein in fresh freezing tissues from 53 patients with lung cancer and 17 normal cases were examined by immuno-histochemistry SP method. Results： Among 53 patients with lung cancer, 19 （36%） showed Kail expression, and a significant difference was shown in comparison of normal lung tissues （82%） （P〈0.01）. The expression rate of Kail protein in early stage of lung cancer was obviously higher than that of late stage （P〈0.05）. The expression rate of Kail protein in Ⅰ and Ⅱdegree of lung cancer was higher than that of m and Ⅳ degree （P〈0.05）. Conclusion： The downregnlation of Kail may indicate metastasis, and is related to malignant degree of lung cancer, and it can be used as a new prognostic marker of lung cancer.

关 键 词：肺癌 KAI1 转移 

分 类 号：R734.2[医药卫生—肿瘤]