颅内混合性生殖细胞肿瘤临床病理学观察  

An analysis of primary intracalvarium mixed germ cell tumor

作　　者：邢传平 哈英娣 钱震 苏勤军 

机构地区：[1]兰州军医兰州总医院病理科,甘肃兰州730050

出　　处：《现代肿瘤医学》2009年第5期838-841,共4页Journal of Modern Oncology

摘　　要：目的:探讨颅内混合性生殖细胞肿瘤的临床病理学特征。方法:应用组织病理学、组织化学和免疫组织化学方法,对2例外科手术病例进行观察。结果:患者临床表现头痛恶心,影像学检查提示颅内占位性病变。组织病理学改变例1为精原细胞瘤、低分化肉瘤与腺癌成分混合,瘤细胞Vimentin(+)、部分CD99(+)、LCA(-)、GFAP(-)、Syn(-),瘤组织富含网状纤维。例2为腺泡样生殖瘤细胞与软骨肉瘤、鳞状细胞癌成分混合。2例肿瘤细胞少部分表达ALPA、AFP,腺癌、鳞癌部分细胞表达EMA、CKl、CKh,软骨肉瘤细胞部分表达S-100、Vimentin。结论:颅内混合性生殖细胞肿瘤非常罕见,肿瘤组织表现双相和多相分化,病理诊断依据组织学和免疫组化标记结果判定,肿瘤伴有癌成分时预后不良。Objective：To investigate the clinicopathological features of primary intracalvarium mixed germ cell tumor. Methods： By means of histological, immunohistochemical and histochemistry methods, the clinical and pathological features of two cases of primary intracalvarium mixed germ cell tumor were analyzed. Results：Patients were 21 and 61 years old and presented with discontinuuity angina. CT, MRI showed intracal mass lesion. In case 1 ,the tumor was composed of spermocytoma and poorly differentiated sarcoma and adenocarcinoma. Immunohistochemical expression of CD99, Vimentin were positive and LCA, GFAP, Syn were negative in sarcoma area. Reticular fiber presented in the tumor tissues. In case 2, the tumor was mixed of chondrosarcoma and squamous cell carcinoma. The tumor ceils were positive for ALAP, AFP. The tumor cells of adenocarcinoma and squamous cell carcinom were positive for EMA, CKpan ,CKh. The tumor cells of chondrosarcoma were positive for S - 100, Vimentin. Conclusion： Primary intracalvarium mixed germ cell tumor is a rare tumor with diphase and muhiphases differentiation. The diagnosis was based on histological, immunohistochemical staining.

关 键 词：生殖细胞肿瘤 混合性 颅内 临床 病理学 

分 类 号：R739.41[医药卫生—肿瘤]