越桔果渣黄酮对腺嘌呤诱导大鼠高尿酸血症肾损伤的防治作用  

THE PREVENTIVE AND THERAPEUTIC EFFECTS OF FLAVONOIDS FROM FRUIT RESIDUES OF VACCINIUM VITIS-IDAEA L.ON ADENINE INDUCED HYPERURICEMIA AND KIDNEY INJURY IN RATS

作　　者：赵赟[1] 赵洪军[1] 朱丹[1] 朱兴磊[1] 张敏[1] 瞿伟菁[1] 

机构地区：[1]华东师范大学生命科学学院,上海200063

出　　处：《营养学报》2009年第2期148-151,共4页Acta Nutrimenta Sinica

基　　金：上海市科技发展基金(No.054358030)

摘　　要：目的研究越桔果渣黄酮(FFV)对腺嘌呤诱导大鼠高尿酸血症、肾损伤的防治作用。方法利用腺嘌呤灌胃法诱导SD大鼠制备高尿酸血症和肾损伤模型,FFV预防治疗3w,测定与高尿酸血症和肾衰相关的各项组织器官和血液生化指标。结果越桔果渣总黄酮可显著降低血清尿酸水平,与别嘌醇的降尿酸效果相当;并能显著降低尿酸氮、肌酐、丙二醛水平和肝脏系数、肾脏系数。结论越桔果渣总黄酮有干预腺嘌呤诱导高尿酸血症和肾损伤的作用。Objective To study the preventive and therapeutic effects of flavonoids from fruit residues of Vaccinium vitis-idaea L. （FFV） on adenine induced hyperuricemia and renal failture in rats. Method SD rats with hyperuricemia and renal failure were induced by adenine intragastrically, and then given FFV for 3 w. The items related with high serum uric acid and kidney injury were observed. Results FFV can effetively lower serum uric acid, having a similar effect to allopurinal, and effectively lower urea nitrogen, creatinine, malonaldehyde level and the relative weights of liver arid kidney. Conclusion FFV can interfere adenine induced hyperuricemia and renal failure in rats.

关 键 词：越桔果渣总黄酮 腺嘌呤 高尿酸血症 肾衰 

分 类 号：R285.5[医药卫生—中药学]