抽动障碍中医证型与血清单胺类物质的相关性研究  

The Correlation Study of Traditional Chinese Medicine Syndrome Type in Tic Disorders and Monoamine Substance in Serum

作　　者：肖光华[1] 吴敏[1] 

机构地区：[1]上海交通大学医学院附属新华医院,上海200092

出　　处：《中国中医急症》2009年第5期745-747,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：上海市卫生局基金资助项目(No.2006L014);上海申康医院发展中心基金资助项目(No.SHDC12007409);上海市中医临床优势专科(专病)第二批建设项目(No.2008YSZK003)

摘　　要：目的观察抽动障碍不同中医证型患者血清多巴胺、去甲肾上腺素等单胺类神经递质的水平,并探讨各证型之间血清神经递质的水平是否存在差别。方法采用化学荧光法测定46例抽动障碍患者(病例组)血清多巴胺、去甲肾上腺素水平,并与40例正常儿童(对照组)进行比较。结果病例组血清多巴胺为0.449μg/ml,对照组为0.210μg/ml;病例组血清去甲肾上腺素为0.227μg/ml,对照组为0.127μg/ml,两组各均值比较,病例组血清多巴胺和去甲肾上腺素均显著高于对照组。病例组外风侵袭、肝风内动型,或兼气郁化火型,或兼脾虚痰聚型,或兼阴虚风动型血清多巴胺水平分别为0.316、0.400、0.235、0.247μg/ml,四者比较有显著性差异;病例组各证型血清去甲肾上腺素水平分别为0.203、0.224、0.144、0.154μg/ml,四者比较差异有显著性。结论抽动障碍患者存在多巴胺和去甲肾上腺素水平异常,且各证型血清多巴胺、去甲肾上腺素水平有明显差异,而尤其以外风侵袭、肝风内动兼气郁化火型水平最高。Objective： To get the level of monoamine neurotransmittes such as dopamine, noradrenaline etc. in tic disorder patients＇ serum and to investigate whether there are some differences of monoamine neurotransmitter between four traditional Chinese mecieine （TCM） types of syndrome. Methods： The levels of the dopamine and the noradrenaline in 46 tic disorder patients（case group） were tested by chemiluminescence technique and compared with that of the 40 normal children. Results： The level of serum dopamine in case group was 0. 449ug/ml and that in control group was 0. 210ug/ml, the level of serum noradrenaline in case group was 0. 227ug/ml and that in control group was 0. 127ug/ml, as well. The concentrations of serum dopamine and noradrenaline in case group was apparently higher than those in control group. The level of serum dopamine of exogenou wind evil invasion, endogenous liver wind type, exogenous wind evil invasion, endogenous liver wind -stagnated qi transforming into fire type, exogenous wind evil invasion, endogenous liver wind - splenic asthenia phlegm gather type, exogenous wind evil invasion, endogenous liver wind -stirring of wind due to deficiency of YIN type in case was partly 0. 316ug/ml, 0. 400ug/ml, 0. 235ug/ml, 0. 247ug/ml. There were significant differences in four types. The noradrenaline was partly 0. 203ug/ml, 0. 224ug/ ml, 0. 144ug/ml, 0. 154ug/ml. There were also some statistical significances in these types. Conclusion： The abnormality of dopamine and noradrenaline in tie disorder patients is occurred. The level of serum dopamine and noradrenaline in all TCM types of syndrome is obviously different. Even while there are some types, such as exogenous wind evil invasion, endogenous liver wind - stagnated qi transforming into fire type, the difference could reach its maximum.

关 键 词：抽动障碍 证型 多巴胺 去甲肾上腺素 

分 类 号：R748[医药卫生—神经病学与精神病学]