多系统萎缩58例临床分析  

CLINICAL ANALYSIS OF 58 CASES WITH MULTIPLE SYSTEM ATROPHY

作　　者：刘举[1] 周红雨[1] 连志云[1] 

机构地区：[1]四川大学华西医院神经内科,成都610041

出　　处：《现代预防医学》2009年第9期1767-1769,共3页Modern Preventive Medicine

摘　　要：[目的]分析多系统萎缩(MSA)的临床特征。[方法]回顾性分析58例临床诊断MSA患者的临床资料。[结果]男性36例,女性22例,发病年龄33～75(55.8±9.3)岁。30(51.7%)例以行走不稳、言语不清等小脑症状为首发症状,22(37.9%)例以自主神经功能障碍为首发症状。37(63.8%)例MSA患者出现3个以上系统同时受累。MSA患者中40(70%)例表现有小脑萎缩;MSA-P患者中4例表现为延髓、脑桥和小脑萎缩。[结论]MSA是一种累及神经系统多部位的变性疾病,男性多于女性,中老年起病,缓慢进展,首发症状以小脑症状最多,其次为自主神经功能障碍。多数患者出现3个以上系统同时受累。MRI表现多以小脑萎缩为主,MSA-P患者也可表现为延髓脑桥小脑萎缩,对MSA诊断有肯定意义。本病暂无特殊治疗,预后差,但有些药物可改善部分患者临床症状。[Objective] To explore the clinical features of multiple system atrophy （MSA）. [Methods] Clinical data of 58 MSA cases were retrospectively analyzed. [Results] There were 36 males and 22 females. the ages of onset were between 33 and 75 years old. The initial symptom of 30 （51.7%） patients was cerebellar symptom; 22 cases were autonomic functional dis-turbance, accounting for 37.9%. Three systems were involved in 37 cases （63.8%）. Cranial MRI of 40 （70%） cases showed cerebellar atrophy and four cases out of MSA-P patients also manifested olivopontocerebellar atrophy. [Conclusion] Multiple system atrophy is an adult onset neurodegenerative disease and progresses relentlessly. The incidence is higher in males than that in females. Three systems are involved in most cases. Cerebellar atrophy predominates in the MRI manifestations and the patients with MSA-P subtype can also exhibit olivopontocerebellar atrophy, which can provide certain diagnostic evidences. Although therapeutic strategies are still limited and the disease evolves with a terrible prognosis, certain medicines do make improvement in some patients.

关 键 词：多系统萎缩(MSA) 临床分析 诊断 

分 类 号：R741[医药卫生—神经病学与精神病学]