余甘子提取物对糖尿病小鼠血糖的影响  

Blood Glucose-reducing Effects of Fructus phyllanthi Fruit Extracts on Diabetic Mice

作　　者：韩刚[1] 原海忠[1] 董月[1] 翟冠玉[1] 范颖[1] 

机构地区：[1]华北煤炭医学院药学系,唐山市新药基础研究重点实验室

出　　处：《食品科学》2009年第9期210-212,共3页Food Science

摘　　要：目的:研究余甘子提取物对糖尿病小鼠血糖的影响。方法:采用小鼠尾静脉注射70mg/kg四氧嘧啶建立小鼠糖尿病模型。分别灌胃给予二甲双胍阳性对照药物、余甘子乙醇提取物、余甘子水提取物,测定糖尿病小鼠血糖浓度的变化。结果:与糖尿病模型组比较,余甘子水提取物降血糖作用明显(p<0.05),余甘子乙醇提取物仅有降血糖趋势,无统计学意义(p>0.05)。结论:余甘子水提取物对四氧嘧啶所致糖尿病小鼠具有显著的降血糖的作用(p<0.05)。In this study, diabetic mice model was established by intravenous injection of 70 mg/kg alloxan. Then the mice were administered with mefformin （the positive control）, and ethanol extract and aqueous extract of Fructus pyhlllanthi fruit by gastric perfusion, respectively, to investigate the effects of ethanol and aqueous extracts on blood glucose level of diabetic mice. The results showed that the aqueous extract can significantly decrease the blood glucose level in diabetic mice （p 〈 0.05）, but there is only a hypoglycemic tendency induced by ethanol extract without statistical significance （p 〉 0.05）.

关 键 词：余甘子 糖尿病 血糖 四氧嘧啶 

分 类 号：R284.2[医药卫生—中药学]