靶向诱导DNA甲基化与肿瘤治疗研究进展  

Advances in targeted induction of DNA methylation and cancer therapy

作　　者：马爱妞[1] 王永祥[1] 周向军[1] 

机构地区：[1]上海交通大学药学院分子与系统药理学实验室,上海200240

出　　处：《中国临床药理学与治疗学》2009年第3期241-244,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：DNA甲基化是表观遗传调控的重要方式之一,它能在转录水平上抑制相关基因的表达,从而引起基因沉默。近年来的研究表明,DNA的甲基化不仅在生物体内自然发生,而且可通过特异的RNA、DNA等靶向诱导产生。肿瘤的细胞中存在癌基因的异常低甲基化,而且这种异常被认为是肿瘤的发病机制之一。因此,通过靶向诱导癌基因甲基化来抑制癌基因的表达、抑制肿瘤生长的方法,为肿瘤治疗提供了一种新的思路。本文就靶向诱导DNA甲基化与肿瘤治疗的临床前研究进展作一简述。DNA methylation is one of the important events in epigenetic regulation. It inhibits gene expression in the transcription level resulting in gene silencing. Recent studies revealed that DNA methylation not only occurs naturally in organism, but also targeting induced by special RNA/DNA. Oncogenesis exist abnormally low methylation in tumor cells, which is considered to be one of the pathogeneses of tumors. Thus inhibition of the expression of oncogenesis and the growth of tumor by targeted induction of DNA methylation provides a new way for cancer therapy. This review summarizes the effects of targeted induction of DNA methylation on cancer therapy in preclinical studies.

关 键 词：DNA甲基化 基因沉默 表观遗传调控 肿瘤治疗 

分 类 号：R73-3[医药卫生—肿瘤]