Are isothiocyanates potential anti-cancer drugs？  

作　　者：Xiang WU Qing-hua ZHOU Ke XU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China

出　　处：《Acta Pharmacologica Sinica》2009年第5期501-512,共12页中国药理学报（英文版）

基　　金：Acknowledgements Research in the authors＇ laboratory is supported in part by the National Natural Science Foundation of China （No 30873035） and the Key Project of the Foundation of Tianjin High Education Commission （No ZD200714）.

摘　　要：Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification. Recent studies show that they exhibit anti-tumor activity by affecting multiple pathways including apoptosis, MAPK signaling, oxidative stress, and cell cycle progression. This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents.Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification. Recent studies show that they exhibit anti-tumor activity by affecting multiple pathways including apoptosis, MAPK signaling, oxidative stress, and cell cycle progression. This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents.

关 键 词：ISOTHIOCYANATE CHEMOPREVENTION anticarcinogenic ANTITUMOR APOPTOSIS cell 

分 类 号：R446.12[医药卫生—诊断学] R979.1[医药卫生—临床医学]