肿瘤相关巨噬细胞促进肿瘤微淋巴管生成的研究进展  

Progression on tumor-associated macrophages in promoting cancer lymphangiogenesis

作　　者：詹庆华[1] 陈维荣[1] 

机构地区：[1]汕头大学医学院,广东汕头515043

出　　处：《国际病理科学与临床杂志》2009年第2期165-169,共5页Journal of International Pathology and Clinical Medicine

摘　　要：恶性肿瘤的侵袭和转移是一个复杂的病理过程,大量的研究显示肿瘤的微淋巴管生成与其淋巴结转移密切相关。近年来的研究发现肿瘤微环境及肿瘤相关巨噬细胞在肿瘤演进中起着极其重要的作用,并且可能是肿瘤演进的关键。本文总结近年来有关肿瘤相关巨噬细胞与肿瘤微淋巴管生成方面的研究成果,着重探讨肿瘤相关巨噬细胞、微淋巴管生成与肿瘤侵袭和转移的关系,为研究肿瘤的发生发展机制提供新思路。The invasion and metastasis of cancer is a complex pathological process. Plenty of studys show that lymphangiogenesis is related with the possibility of cancer cell＇ s migratiation in the regional lymph nodes and lymphoid organs. Recently, lots of studys find that microenvironment, especially tumor-associated macrophages （TAM）, plays an indispensable role in cancerous progression, and it might be crucial in the invasion and metastasis. Our paper reviewed the related research fingdings and discussed the relationship among TAM, lymphagenese and the behavior of cancerous invasion and metastasis, so that it might offer a new method to explore the hypostasis of carcinoma.

关 键 词：肿瘤相关巨噬细胞 微淋巴管生成 肿瘤侵袭 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]