晚期牙龈癌选择性动脉灌注化疗的临床观察  

Clinical observation on selective intra-arterial infusion chemotherapy in advanced carcinoma of gingiva

作　　者：蒙志斌[1] 武宁妮[1] 欧阳欣[1] 欧盛秋[1] 

机构地区：[1]广西医科大学附属肿瘤医院介入治疗科,广西南宁530021

出　　处：《中华肿瘤防治杂志》2009年第6期470-472,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了观察动脉灌注顺铂DDP、5-FU、BLM治疗晚期牙龈癌的疗效,102例晚期牙龈癌患者均用DDP、5-FU、BLM方案治疗剂量:DDP60～80mg/(m2.d1),5-FU500～1000mg/(m2·d1),BLM8～16mg/(m2.d1)。给药方法随机分为动脉灌注治疗组(A组)51例,静脉滴入治疗组(B组)51例。结果近期缓解率A组76.47%、B组49.01%,两组比较,χ2=8.22,P=0.0047;中位生存期A组20个月、B组15个月;生存>1年患者A组占76.47%、B组占56.86%,两组比较χ2=4.412,P=0.036;>2年生存A组占49.02%,B组占29.41%,两组比较χ2=4.113,P=0.046。初步研究结果提示,动脉灌注治疗晚期牙龈癌的临床疗效优于静脉滴入疗法。To objective of this study was to observe the clinical effects of intra-arterial infusion chemotherapy of DDP,5-FU and BLM dosage： DDP 60-80 mg/（m^2·d1）, 5-FU 500-1 000 mg/（m^2·d1）, BLM 8-16 mg/（m^2·d1） on patients with advanced carcinoma of gingiva. A total of 102 patients with advanced carcinoma of gingiva were divided randomly into am intra-arterial infusion therapy （A） group （51 cases） and intravenous injection therapy （B） group （51 cases）. In the A group, the remission rate was 76.47%, and in the B group, was 49.01%. There was a significant difference between the two groups （χ^2=8.22, P=0.004 7）. The A group’s median survival period was 20 months, while the B group’s was 15 months. The survival rate （more than 1 year） was 76.47% in A group, and 56.86% in B group. There was a significant difference between the two groups （χ^2=4.412, P=0.036）. The survival rate （more than 2 year） was 49.02% in A group, and 29.41% in B group. There was a significant difference between the two groups （χ^2=4.113, P=0.046）. The intra-arterial infusion chemotherapy has a significantly better clinical curative effect than the intravenous injection therapy in the treatment of patients with advanced carcinoma of gingiva.

关 键 词：牙龈肿瘤/药物疗法 输注 动脉内 治疗结果 

分 类 号：R739.82[医药卫生—肿瘤]