青年人与中老年人食管癌外科治疗临床疗效的比较研究  

Comparative Study on clinical results of young and elderly patients treated by surgical resection for esophageal cancer

作　　者：任鹏[1] 赵锡江[1] 张熙曾[1] 

机构地区：[1]天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院食管肿瘤科,天津300060

出　　处：《中华肿瘤防治杂志》2009年第7期526-528,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:分析青年人食管癌的临床特征及其手术治疗效果,并与中老年人食管癌进行对比。方法:以同期手术治疗随访完整的中老年食管癌患者1936例(≥40岁)为对照,对手术治疗的青年人食管癌患者78例(<40岁)临床资料进行回顾分析。结果:<40岁青年人食管癌共78例,占同期食管癌总数的2.14%,接受手术治疗的48例(61.5%),手术切除率为81.5%,低于其他年龄组的90.1%。青年人食管癌淋巴结转移率为52.1%,高于中老年组的39.0%;手术后并发症发生率和死亡率分别为2.1%和0,均低于中老年组的9.6%和3.3%;术后1、3和5年生存率分别为74.4%、38.5%和30.8%,中老年组分别为68.4%、32.8%和23.8%,两者差异无统计学意义,P>0.05。结论:青年人食管癌好发于有重度吸烟史的男性,与中老年组食管癌比较,肿瘤分期较晚,淋巴结转移率高,手术切除率低,但其预后并不比中老年组差,手术及辅助治疗是首选治疗手段。OBJECTIVE： To analyze the clinicopathological features and surgical efficacy of young patients with esophageal carcinoma, and discuss the same and difference between it with elder patients. METHODS： To study retrospectively the materials of 78 young patients（〈40 years） with esophageal carcinoma undergone operation, and 1 936 elder patients（≥40 years） with esophageal carcinoma were treated in the corresponding period as control group. RESULTS： A total of 78 patients with esophageal carcinoma accepted in our hospital were younger than 40 years old（2.14 % ）, 48 of them were performed operation, the rate of lymph node metastasis（52.1 % ） was higher than that of control group（39. 0%）, the rate of resectability was 81.5%, less than 90.1% of control group. The postoperative complication and mortality were 2.1% and 0, while 9.6 % and 3.3% in control group. No significant difference in the 1-, 3-, and 5-year survival rates was observed between younger patients （74. 4%, 38.5% and 30.8%, respectively） and older patients （68.4%, 32.8% and 23.8%, respectively）. CONCLUSIONS： esophageal carcinoma in young patients often arises at male with habit of excessive smoking. In contrast to older patients, the tumor in young patients has advanced stage, higher rate of lymph node metastasis and less rate of resectability, while the prognosis of young patients was not poor than older patients , surgery and adjunctive radiochemotherapy are the first choice for treatment.

关 键 词：食管肿瘤/外科学 青年 外科治疗 预后 

分 类 号：R735.1[医药卫生—肿瘤]