超临界CO2快速膨胀制备鱼腥草挥发油脂质体  

Preparation of Liposome of Volatile Oil from Houttuynia cordata Thunb.by Rapid Expansion of Supercritical Carbon Dioxide

作　　者：文震[1] 刘波[1] 李琼[2] 郑宗坤[1] 游新奎[1] 蒲一涛[1] 

机构地区：[1]深圳大学化学与化工学院,广东深圳518060 [2]华南理工大学化工与能源学院,广东广州510640

出　　处：《过程工程学报》2009年第2期350-354,共5页The Chinese Journal of Process Engineering

基　　金：国家自然科学基金资助项目(编号:20606013);广东省绿色化学产品技术重点实验室开放基金资助项目(编号:GC200701)

摘　　要：采用改进的超临界CO2快速膨胀方法制备了鱼腥草挥发油脂质体,并对其进行了表征.考察了压力、温度、共溶剂乙醇用量等因素对脂质体制备的影响,在压力30MPa、温度338K及乙醇用量15%条件下,脂质体包封率为83.2%,载药量为5.2%,平均粒径为332.5nm.脂质体包封率、溶出度、稳定性等理化性质均符合中国药典的规定,载药量满足注射剂给药量的要求.The liposome of volatile oil from Houttuynia cordata Thunb. was prepared by modified rapid expansion of supereritical solutions （RESS）, and physicochemical properties of liposome were characterized. The effects of pressure, temperature of supercritical CO2 and cosolvent （CH3CH2OH） amount on the liposome formation process were examined. Entrapment rate, drug loading, and average size of liposome were obtained as 83.2%, 5.2% and 332.5 nm respectively under the conditions of 30 MPa, 338 K and CH3CH2OH 15%. The results showed that the physicochemical properties including entrapment rate, dissolution rate and stability conformed to the standards of Chinese pharmacopoeia, and drug loading met the needs of injection dosage.

关 键 词：脂质体 超临界 鱼腥草 挥发油 

分 类 号：TS201.2[轻工技术与工程—食品科学]