虾青素对大鼠乙酸性胃溃疡的治疗作用  

Therapeutic effect of astaxanthin on acetic acid-induced gastric ulcer in rats

作　　者：杨琼[1] 张真[2] 朱铉[2] 阮航[2] 扶艳[2] 

机构地区：[1]延边大学药学院,吉林延吉133000 [2]厦门大学医学院药学系,福建厦门361005

出　　处：《药学学报》2009年第5期558-560,共3页Acta Pharmaceutica Sinica

基　　金：福建省自然科学基金资助项目(2008J0115);福建省新世纪优秀人才支持计划项目

摘　　要：由多因素诱发的失控性胃酸分泌及胃防御功能损害而引起的胃溃疡是严重的全球性问题。近年来，氧自由基在胃黏膜损伤中的作用日益受到重视。许多研究表明，氧自由基所致的细胞损害是很多病理过程中组织损伤的共同方式。虾青素（astaxanthin，3，3′-二羟基-β，β′-胡萝卜素-4，4′-二酮）为一种类胡萝卜素的含氧衍生物，是一种广泛存在于生物体的红色素。虾青素能有效地淬灭活性氧，是一种极具发展潜力的抗氧化剂。This study is to investigate therapeutic effect of astaxanthin on acetic acid-induced gastric ulcer in rats. Rats were divided into control group, ulcer control group, and astaxanthin （5, 10, and 25 mg·kg^-1） groups at random, 8 rats in each group. After administered for 10 days consecutively, all the rats were sacrificed. The area of ulcer and the levels of MDA, SOD, CAT and GSH-Px in gastric mucosa were measured. Compared with ulcer control group, in astaxanthin （5, 10, and 25 mg·kg^-1） groups, the area of ulcer was decreased significantly. Level of MDA decreased while activities of SOD, CAT and GSH-Px increased （P 〈 0.05）. Astaxanthin has good therapeutic effect on acetic acid-induced gastric ulcer in rats. Eliminating free radical and improving local blood circulation of the ulcer may be the mechanism of action.

关 键 词：虾青素 乙酸性胃溃疡 氧自由基 酶活性 

分 类 号：R965[医药卫生—药理学]