戊型肝炎病毒感染与胰腺癌发病的相关性临床分析  

Clinical Analysis of Correlation Between Pancreatic Cancer and Hepatitis E Virus Infection

作　　者：郑宗富[1] 刘奇才[2] 徐美华[2] 

机构地区：[1]南京军区福州总医院第476分院检验科,福建福州350025 [2]福建医科大学附属第一医院检验科,福建福州350005

出　　处：《山西中医学院学报》2009年第2期58-59,共2页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:分析戊型肝炎病毒(HEV)感染与胰腺癌发病的相关性。方法:以12例HEV感染的胰腺癌患者(感染组)和47例非HEV感染的胰腺癌患者(非感染组)为研究对象,收集相关临床资料包括胰腺、肝脏的病理表现等,分析HEV感染的胰腺癌患者的临床特征,并且用HEVRNA直接测序技术对合并HEV感染的胰腺癌患者的胰腺组织进行HEV定位分析。结果:感染组合并肝癌、肝硬化的概率高于非感染组,感染组胰腺癌发病的平均年龄较非感染组提前8.5年,2例HEV感染的胰腺癌患者的胰腺组织中检测到HEVORF2片段。结论:HEV感染与胰腺癌发病存在相关性。Objective：To analyse the correlation between pancreatic cancer and hepatitis E virus（HEV）infection. Methods：The related clinical data containing 12 pancreatic cancer patients combined with HEV infection（infection group）and 47 pancreatic cancer patients （non-infection group）were collected. And HEV ORF2 segments in pancreas tissue of patients was detected by RNA direct sequencing technology. Results ：The incidence of liver cancer or/and liver cirrhosis was higher in infection group than that in non-infection group（P〈0.05）. HEV ORF2 segments were found in pancreas tissue of two patients in infection group. Conclusion：Highly statistically correlation was found between HEV infection and pancreatic cancer.

关 键 词：戊型肝炎病毒 胰腺癌 HEV ORF2片段 

分 类 号：R575.1[医药卫生—消化系统]