法莫替丁顿服治疗消化性溃疡110例疗效观察  

Observation on the Efficacy of Draught of Famotidine in 110 Cases of Peptic Ulcer

作　　者：李映章[1] 

机构地区：[1]仲恺农业工程学院医院,广州510225

出　　处：《保健医学研究与实践》2009年第2期39-39,41,共2页Health Medicine Research and Practice

摘　　要：目的探讨法莫替丁顿服治疗消化性溃疡的临床疗效。方法将110例经胃镜确诊且无合并症的活动性溃疡患者随机分2组。顿服组58例,给予法莫替丁40mg,每晚顿服;常规服法组52例,给予法莫替丁20mg,每日2次。均治疗6周,观察2组的临床疗效、副反应和半年复发率。结果顿服组治愈率为65.5%,常规服药组为69.2%,两者疗效的差异无统计学意义(χ2=1.06,P>0.05);顿服组出现副反应的种类及机率低于常规服药组;两组半年复发率的差异无统计学意义(P>0.05)。结论顿服与常规服法莫替丁治疗消化性溃疡疗效大致相同,前者比后者的副反应小,口服次数减少,患者易接受,值得推广和进一步探讨。Objective To investigate the efficacy of famotidine at draught in the treatment of peptic ulcer. Method 110 cases of active ulcer without complications confirmed by endoscope were randomly divided into two groups treated with famotidine for 6 weeks： one troup with 58 cases taking 40mg at a draught every night while the other group with 52 cases taking 20mg twice per day. Clinical efficacy,adverse reaction and semi-annual relapse rate were observed. Results The cured rate was 65.5% in group at one draught,while 69.2% in the other group. There was no significant difference between them （χ^2= 1.06,P〉0.05） ; The types and incidence rate of adverse reaction in group at one draught were less or lower than that in the other group. The difference in semi-annual relapse rate between two groups did not have statistic significance （P〉0.05）. Conclusion The efficacy of administration at one draught and in conventional way for peptic ulcer treatment are about the same. But the former administration method has mild side effect, less oral administration times and thus is accepted readily by patients,so it should be recommended for a wider use and further assessment.

关 键 词：法莫替丁 顿服 疗效 

分 类 号：R573.1[医药卫生—消化系统]