乳腺癌中EGFR、p53和C-erbB-2基因蛋白表达及意义  

Expression and significance of EGFR,p53 and C-erbB-2 gene proteins in human breast cancer

作　　者：赵荧[1] 贾峰 田亚汀[1] 薄爱华[1] 

机构地区：[1]河北北方学院实验中心,张家口075029 [2]河北北方学院大学生科协,张家口075029

出　　处：《江苏医药》2009年第5期504-505,共2页Jiangsu Medical Journal

基　　金：河北省科技厅课题(03276117)

摘　　要：目的探讨上皮生长因子受体(EGFR),p53和C-erbB-2基因蛋白在乳腺癌中的表达及意义。方法收集乳腺癌标本98例,用SP免疫组织化学方法,检测EGFR、p53和C-erbB-2基因蛋白的阳性率。结果EGFR、p53和C-erbB-2在乳腺癌中的阳性率分别为61.22%、46.93%和54.08%。浸润性癌中EGFR和p53阳性率明显高非浸润性癌(P<0.05),淋巴结转移组明显高于无转移组(P<0.05)。结论EGFR、p53和C-erbB-2过表达是乳腺癌预后不良的重要指标。Objective To explore the expression and significance of epidermal growth factor receptor（EGFR） ,p53 and C-erbB-2 gene proteins in human breast cancer. Methods EGFR, p53 and C-erbB-2 of breast cancer were examined by SP imrnunohistochemiacl method in 98 cases. Results The positive expression rates of EGFR, p53 and C-erbB-2 were 61.22%, 46.93% and 54.08%, respectively, in breast cancer. The positive rates of p53 and EGFR in invasive carcinoma were higher than those in norrinvasive carcinoma （P〈0.05）. Conclusion Overexpression of EGFR, p53 and C-erbB-2 in human breast cancer may sevre as the important markers for evaluating the prognosis.

关 键 词：乳腺癌 上皮生长因子受体 P53 C-ERBB-2 

分 类 号：R734[医药卫生—肿瘤]