以淋巴增殖性疾病为表现的套细胞淋巴瘤的临床与诊断分析  

Clinical analysis and diagnosis of mantle cell lymphoma presented as lympho-proliferative disease

作　　者：李增军[1] 吴瞳[1] 邱录贵[1] 李业楠[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院实验血液学国家重点实验室,天津300020

出　　处：《临床血液学杂志》2009年第3期225-228,共4页Journal of Clinical Hematology

基　　金：天津市自然科学基金资助项目(No:06YFJMSC08500)

摘　　要：目的:研究以慢性B淋巴细胞增殖性疾病(B-LPD)为表现的套细胞淋巴瘤(MCL)的临床特点与诊断。方法:对过去7年间以LPD为主要表现并可诊断为MCL的15例患者的临床特点和诊断进行回顾性分析。结果:①15例MCL中,依靠病理及CyclinD1诊断6例,依靠典型的免疫表型特征诊断9例;②部分以LPD表现的MCL患者临床表现、瘤细胞形态与慢性淋巴细胞白血病(CLL)难以区别,而免疫表型分析不符合CLL特点;③淋巴结或脾脏病理检查结合免疫组织化学是诊断MCL的主要依据,典型的免疫表型对MCL的诊断价值值得探讨。结论:部分MCL患者以广泛侵犯骨髓的LPD发病,对不典型LPD应进行病理检查明确诊断,而不能按CLL处理,以免贻误治疗。Objective：To study the clinical features and diagnosis of mantle cell lymphoma presented as lympho-proliferative disease. Method：The clinical features and diagnosis of 15 cases of MCL presented as lympho-proliferative disease were retrospectively analyzed. Result：（1） Six of the 15 cases of MCL were diagnosed by histopathology and immunohistochemistry, and the other nine cases were diagnosed by immunophenotype in addition to the features of B-LPD;（2）The MCL patients presented as B lympho-proliferative disease shared the similar clinical features and morphological characteristics with CLL, while their immunophenotypes were valuable for differential diagnosis;（3）Histopathological examination of lymph node or spleen was the main method for confirmation diagnosis and the value of typical immunophenotype in the diagnosis deserved further discussion. Conclusion： Some MCL patients presented like B-LPD and the confirmed diagnosis was required rather than simply treated as CLL.

关 键 词：套细胞淋巴瘤 淋巴细胞增殖性疾病 诊断 

分 类 号：R733.4[医药卫生—肿瘤]