急性脑血管病病变性质严重程度与血浆内皮素-1浓度的关系  

RELATIONSHIP OF FATHOLOGIC PROPRTY AND SEVERITY TO PLASMA ENDOTHELIN-1 IN ACUTE CEREBROVASCULAR DISEASE

作　　者：李春盛[1] 田茹敏[1] 李爱民[1] 刘青斐 谢秀华[1] 

机构地区：[1]北京军区总医院急诊科,北京100700

出　　处：《急诊医学》1998年第1期27-29,共3页

摘　　要：目的：主要是探讨急性脑血管病患者病变性质、严重程度与血浆内皮素－1（ET－1）浓度的关系。方法：应用放射免疫方法测定87例急性脑血管病人血浆ET－1浓度并与42例正常人进行比较。结果：脑出血与脑梗塞组血浆ET－1浓度明显高于对照组（P＜0．001），而脑梗塞组血浆ET－1浓度比脑出血组升高，但未有统计学意义（P＞0．05）。急性脑血管病重型者比轻型者血浆ET－1浓度明显升高（P＜0．01），合并高血压者血浆ET－1浓度较正常对照组显著升高（P＜0．001），而与血压正常组相比较二者无显著性差异（P＞0．05）。结论：提示急性脑血管病患者血浆ET－1浓度升高与病变严重程度、血压升高有一定关系，与病变性质虽无统计学意义，但脑梗死者也较脑出血组升高，表明ET－1作为一种内源性血管活性肽在急性脑血管病的预后和发病机制方面是一种有害的介质。Aim To explore the relationship of pathologic property and severity to plasma ET-1 levels in acute cerebrovascular diseases. Methods The levels of plasma E-1 were determined by radioimmunoassay in 42 healthy subjects and 87 cases with acute cerebrovascular diseases. Results It showed that plasma ET-1 levels in patients with cerebral hemorrhage and cerebral infarction were significantly higher than that in the healthy controls (P <0. 001 ). Though the plasma ET-1 levels in cerebral infarction were higher than that in cerebral hemorrhage, there was not statistically different (P >0. 05). The plasma ET-1 leve1s in severe type of acute cerebrovascular diseases were significantly higher than that in mild type of acute cerebrovascular diseases (P <0. 01). In comparison with healthy controls, plasma ET-1 leve1s in acute cerebrovascular disease with hypertension and without hypertension were higher (P<0. 001),but there was no significantly difference in plasma ET-1 levels between acute stroke with hypertension and without hyPertension (P >0. 05). Conclusion This study suggested that the plasma ET-1 levels were related to pathologic property and severity of acute cerebrovascular diseases.

关 键 词：急性 脑血管病 内皮素 病变性质 严重程度 

分 类 号：R743.02[医药卫生—神经病学与精神病学]