雷公藤多甙对兔眼人工晶体表面细胞学反应的影响  

Effects of TWP on surface cellular response of IOL

作　　者：周朝晖[1,2,3] 何守志[1,2,3] 梁延杰[1,2,3] 

机构地区：[1]解放军304医院眼科 [2]解放军总医院眼科 [3]解放军304医院病理科

出　　处：《军医进修学院学报》1998年第1期46-48,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：研究兔眼人工晶体（ＩＯＬ）表面炎性细胞学反应的病变特征，估价雷公藤多甙（Ｔｒｙｐｔｅｒｇｉｕｍｗｉｌ－ｆｏｒｄｉｐｏｌｙｇｌｙｃｏ－ｓｉｄｉｕｍ，ＴＷＰ）的治疗效果及其抗炎作用的机制。方法：青紫蓝兔２７只，分为人工晶体囊袋内植入组；雷公藤多甙治疗组；激素治疗组，术后１ｄ、７ｄ、１４ｄ摘除人工晶体，作光镜和扫描电镜检查，计数炎性细胞数，采用ＳＡＳ软件包，对统计资料作方差分析。结果：术后人工晶体表面有明显的炎性细胞，雷松藤治疗组人工晶体表面炎性细胞沉着低于激素治疗组，差异有统计学意义。结论：雷公藤多甙治疗能显著降低人工晶体表面的炎症反应，雷公藤治疗优与激素治疗，这可能与雷公藤多甙的抗炎作用和免疫抑制作用有关。Objective:To observe the pathological changes of the posterior chamber lens, and the effects of Tryptergium Wilfordii Polyglycosidium (TWP) on inflammatory cells of IOL after cataract extraction and intraocular lens (IOL) implantation in rabbits.Methods:Twentyseven adult pigmented rabbits were equally divided into three groups: (1)The IOL were placed into the capsular bag after lens extraction, (2)Rabbits received TWP therapy after IOL implantation, and (3)Rabbits received prednisone therapy after IOL implantation. IOLs were extracted on days 1、7 and 14 after IOL implantation, and the pathological changes of IOLs were observed with light microscopy and scanning electron microscopy, and the number of inflammatory cells of IOLs wre also counted. The data were analyzed by SAS variance analysis software.Results:It was found that the revarious forms of inflammatory cells on the IOL surface after cataract extraction. The numberof the inflammatory cells on the IOL surface was significantly lower in TWPtreated group than that of the steroidtreated group.Conclusion:The current study offers that TWP is effective in reducing postoperative inflammatory response of on IOL, and it is more effective than steroid.

关 键 词：雷公藤 皂甙 人工晶体 表面细胞学 

分 类 号：R779.66[医药卫生—眼科] R285.5[医药卫生—临床医学]