胰腺内分泌肿瘤细胞成分的免疫组织化学观察及其对肿瘤起源的探讨  

Immunohistochemical observations on cell constituents of pancreatic endo- crine tumors and study of their origin

作　　者：李继光[1] 詹勇[1] 曲恒春[1] 郑新宇[1] 田雨霖[1] 沈魁[1] 

机构地区：[1]中国医科大学第一医院外科

出　　处：《中华消化杂志》1998年第1期21-23,共3页Chinese Journal of Digestion

摘　　要：目的探讨胰腺内分泌肿瘤的生物学起源。方法应用链菌素亲生物素－过氧化物酶标免疫组织化学技术（Ｓ－Ｐ法）对５２例胰腺内分泌肿瘤（胰岛素瘤３２例，非功能性胰腺内分泌肿瘤２０例）瘤细胞内胰岛素、胰高血糖素、舒血管肠肽、生长抑素、胃泌素、Ｐ一物质、促肾上腺皮质激素、绒毛膜促性腺激素及５－羟色胺等９种激素或激素类物质的分布进行了观察。结果６５。５％（１３／２０）的非功能性胰腺内分泌肿瘤的细胞具有合成与低存激素的功能．３２．７％（１７／５２）胰腺内分泌肿瘤可含有分泌异位激素的细胞，６３．５％（３３／５２）的胰腺内分泌肿瘤是由多种内分泌细胞所构成。结论支持胰腺内分泌肿瘤是由胰腺内分泌于细胞起源的理论。Objectives To discuss the biochemical origin of pancreatic endocrine tumors. Methods Expression of insulin, glucagon, VlP, somatostatin, gastrin, substance P, ACTH, HCG and 5-HT in the tumor cell were investigated in 52 cases with pancreatic endocrine tumor (32 cases with insulinoma and 20 cases with non-functional pancreatic endocrine tumor) by S-P immunohistochemical staining. Results 65.5% (13/20) stained positive for one or more hormones in non-functional pancreatic endocrine tumor, 32.7%(17/52) was positive for ectopic hormones of pancreas and 63.5% (33/52) stained positive for multiple hormones in all 52 cases. Conclusions These findings support the theory that various pancreatic endocrine tumors arise from a pancreatic endocrine stem cell. [

关 键 词：胰腺素瘤 内分泌肿瘤 免疫组化 肿瘤发生 

分 类 号：R735.902[医药卫生—肿瘤]