双相Ⅰ型障碍躁狂发作患者血浆孤啡肽水平的初步测定  

A Preliminary Study of Orphanin FQ in BipolarⅠDisorder Patients with Manic Episode

作　　者：王丽娜[1] 刘兰芬[2] 刘同洲[2] 张敬悬[2] 

机构地区：[1]山东大学医学院,济南250012 [2]山东省精神卫生中心,济南250014

出　　处：《中国心理卫生杂志》2009年第5期332-334,339,共4页Chinese Mental Health Journal

基　　金：山东省卫生厅科研基金(2005HW115)

摘　　要：目的:初步探讨双相Ⅰ型障碍躁狂发作患者的血浆孤啡肽(OFQ)水平。方法:应用放射免疫分析(RIA)法分别测定26例双相Ⅰ型障碍躁狂发作患者和31例正常人血浆OFQ浓度。结果:躁狂组血浆OFQ水平[(11.29±3.28)pg/ml]低于对照组[(13.92±4.53)pg/ml],P<0.05。躁狂组OFQ水平与Bech-Rafaelsen躁狂量表总分呈负相关(r=-0.75,P<0.01)。血浆OFQ水平的影响因素主要有工作、接触、敌意/破坏行为、性兴趣、睡眠、意念飘忽、患者的受教育程度(β=-1.121,-0.969,0.265,0.455,0.407,0.333,-0.123;P均<0.01)。结论:孤啡肽可能参与双相Ⅰ型障碍躁狂发作的发生机制。Objective： To study the changes of plasma orphanin FQ （ OFQ ） levels in bipolar I disorder patients with manic episode. Methods： The concentrations of plasma OFQ of 26 bipolar l disorder patients with manic episode （ BM group） and 31 healthy adults Ⅰ control group ） were measured by radioimmunoassay （ RIA ） . Results： The levels of plasma OFQ in BM group were lower than that in control group [ （ 11.29 ±3.28） pg/ml vs. （ 13.92±4. 53 ） pg/ml, P 〈0. 05 ] . There was a significant negative correlation between OFQ levels and BRMS in BM group （ r = - 0. 75, P 〈 0. 01 ） . Many factors affected the levels of plasma OFQ, including hostility/destroy behavior, flight of ideas, education, etc. Conclusions： The changes of plasma OFQ levels may play a role in the pathogenesis of bipolar I mania.

关 键 词：双相情感障碍 孤啡肽 病例对照研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学]