重症肌无力患者血乙酰胆碱酯酶活性测定及其临床意义  

Determination of activity of blood acetylcholin esterase in myasthenia gravis patients and its clinical significance

作　　者：应智林[1] 周君富[1] 张扬达[1] 

机构地区：[1]浙江医科大学附属第二医院神经科

出　　处：《临床神经病学杂志》1998年第1期10-12,共3页Journal of Clinical Neurology

摘　　要：检测６３例重症肌无力患者和５０例正常健康人血浆乙酰胆碱酶（Ｐ－ＡｃｈＥ）活性、红细胞乙酰胆碱酯酶（Ｅ－ＡｃｈＥ）活性。结果，患者组的Ｐ－ＡｃｈＥ平均活性和Ｅ－ＡｃｈＥ平均活性皆显著高于对照组（Ｐ＜０．００１）。提示重症肌无力的发病机制除了自身免疫因素外，还有乙酰胆碱酯酶活性改变的因素。Activity of plasma acetylcholin esterase(PAchE) and erythrocyte acetylcholin esterase(EAchE) in 63 myasthenia gravis(MG) patients and 50 healthy volunteers was determined.The results showed that the mean activity values of both PAchE and EAchE in MG group were significantly higher than those in control group(P<0.001).It is suggested that the activity changes of acetylcholin esterase in patients blood are a pathgenetic factor of MG along with autoimmunity.

关 键 词：重症肌无力 乙酰胆碱酯酶 测定 

分 类 号：R746.1[医药卫生—神经病学与精神病学]