卒中患者血清同型半胱氨酸水平与大动脉病变的关系  

Relationship of plasma homocysteine level and pathological change of large artery in stroke patients

作　　者：彭斌[1] 高山[1] 于丙琦 朱迎慧 汪波[1] 

机构地区：[1]中国医学科学院北京协和医院神经科,北京100730 [2]山东临沂中医院神经科,山东临沂276002 [3]郑州铁路中心医院神经科,河南郑州450052

出　　处：《基础医学与临床》2009年第5期519-521,共3页Basic and Clinical Medicine

摘　　要：目的确定急性缺血性卒中患者中同型半胱氨酸(Hcy)水平与脑血管粥样硬化病变程度的关系。方法采用经颅多普勒(TCD)、头核磁血管成像(MRA)或脑血管造影(DSA)评估152名患者颅内外病变血管数,用狭窄或闭塞的脑血管数来反映颅内外大动脉粥样硬化程度。结果低同型半胱氨酸组83人,Hcy为(15.31±3.08)μmol/L,病变血管数量:(1.86±1.51)支;高同型半胱氨酸组69人,Hcy为(34.47±21.38)μmol/L,病变血管数量为:(1.52±1.46)支。两组间病变血管数量没有差异。Spearman相关分析显示,同型半胱氨酸与颅内外大血管病变无关。结论高同型半胱氨酸与缺血性卒中患者颅内外大动脉粥样硬化病变严重程度无关。同型半胱氨酸可能只是血管病变过程中的标志物。Objective To determine the association between homocysteine and severity of large cerebral artery atherosclerosis. Methods Total 152 ischemic stroke patients were evaluated using transcranial Doppler （TCD） , magnetic resonance angiography （MRA）or digital substraction angiography （DSA）. Severity of cerebral artery atherosclerosis was scaled by number of stenosed or occluded artery. Results There were 83 patients in low level homocysteine group with mean Hcy level （15.31±3.08）μmol/L, while 69 patients in high level homocysteine group with mean Hcy （34. 47±21.38） μmol/L. Number of abnormal intra-and extra-artery was 1.86±1.51 and 1.52±1.46 respectively. No significant difference was demonstrated in the number of abnormal artery between two groups. No correlation was noted between Hcy and number of abnormal artery. Conclusion There is no relationship between high homocysteine and severity of large cerebral artery atherosclerosis in ischemic stroke patients. Homocysteine might be the marker of the disease.

关 键 词：同型半胱氨酸 缺血性卒中 动脉粥样硬化 

分 类 号：R743.32[医药卫生—神经病学与精神病学]