膝关节滑膜弥漫型巨细胞瘤手术联合放疗的中长期疗效  

Operation combined with radiotherapy as treatment for diffuse type giant cell tumours of knee

作　　者：李方明[1] 孙笑非[2] 聂青[1] 宁浩勇[3] 朱奇[1] 康静波[1] 张军[1] 

机构地区：[1]北京海军总医院放射治疗中心,100037 [2]北京海军总医院骨科,100037 [3]北京海军总医院病理科,100037

出　　处：《临床肿瘤学杂志》2009年第4期323-326,共4页Chinese Clinical Oncology

摘　　要：目的:探讨膝关节弥漫型巨细胞瘤手术联合放射治疗的效果,以提高对该病的认识和诊治水平。方法:对我院1997年9月～2008年7月间收治的10例膝关节弥漫型巨细胞瘤患者进行临床疗效分析。所有患者均经关节镜手术,并经术后病理确诊。放疗采用德国西门子直线加速器6MV-X线照射,对1例肉眼全切除者照射剂量20Gy/10次;对不全切除者则30Gy/15次,均为5次/周。结果:手术联合放射治疗的9例患者中,其中8例患者获得2～10年(平均5年)随访。术后放疗者均未见肿瘤复发及症状复发;关节功能恢复良好。Lysholm关节功能评分由术前平均53.7分增加到87.5分。未发现急性或迟发性放射并发症。术后1例未及时放疗,1例未放疗,2例均在术后3个月复发。结论:膝关节弥漫型巨细胞瘤术后容易复发,术后联合放疗具有明显的预防肿瘤复发作用,无明显的放疗并发症,患者关节功能恢复良好。Objective：To investigate the effect of radiotherapy as a postoperative treatment of diffuse-type giant cell tumours of knee.Methods：From September 1997 to July 2008,10 patients with diffuse-type giant cell tumours got operation,and 9 patients were treated with radiotherapy after operation.The patients were performed by 6MV-X rays.Total dose was 20-30Gy/10-15f.Results：Eight of the 9 patients were followed up 60 months（range 24 to 120 months）.All patients had seen no recurrence.Lysholm scale was improved from 53.7 to 87.5 in follow up.None had evidence of acute adverse effects,and late effects were not found.Conclusion：Diffuse-type giant cell tumours of knee after surgical procedures is easy for recarrence.These results demonstrate that radiotherapy were an effective modalily in the treatment of prevention recurrence and none had evidence of radiotherapy complications.All patients showed good-to-excellent fuction and were able to return to their previous level of activity.

关 键 词：膝关节 弥漫型巨细胞瘤 手术 放射治疗 

分 类 号：R730.262[医药卫生—肿瘤] R730.55[医药卫生—临床医学]