抑癌基因LKB1在肺癌研究中的进展  

Advances on LKB1 in the study of lung cancer

作　　者：张军华[1] 陈海泉[1,2] 

机构地区：[1]上海交通大学医学院附属上海市第六人民医院胸外科,上海200233 [2]复旦大学附属肿瘤医院胸外科,上海200032

出　　处：《中国癌症杂志》2009年第4期309-312,共4页China Oncology

摘　　要：大约30%的非小细胞肺癌患者中存在LKB1的功能性缺失突变,而肺癌小鼠模型的研究结果也表明LKB1的缺失很大程度上促进了肺癌的发病及进展,而且LKB1的缺失突变在促进肺癌组织类型的分化和肺癌转移中扮演着相当重要的角色,这充分说明LKB1是一个非常重要的抑癌基因。然而目前还未有充分的证据显示出LKB1的功能性缺失突变与肺癌预后有关,针对这种情况,本文对近年来LKB1在肺癌领域中的研究进展作一综述。Recent studies have shown that the loss-of-function LKB1 mutations occur in approximately 30% of human non-small cell lung cancer（NSCLC）. Studies from lung cancer animal models have demonstrated that functional loss of LKB1 dramatically promotes lung cancer invasion and progression, underscoring the essential role of LKB 1 as a potent tumor suppressor involved in lung cancerigenesis, differentiation and metastasis. However, the relationship between loss-of-function LKB1 mutations and lung cancer prognosis remain largely unclear, therefore, we summarized the progress of the research on LKB 1.

关 键 词：肺癌 LKB1 抑癌基因 异常表达 

分 类 号：R730.231[医药卫生—肿瘤]