抗Scl-70和抗Jo-1抗体在系统性硬皮病和皮肌炎中的临床意义  

Clinical Significancc of AntiScl70 and AntiJo1 in Systemic Scleroderma and Dermatomyositis.

作　　者：王万卷[1] 马韵琴[1] 刘丹亚[1] 张盘谏 陈庆秀 

机构地区：[1]西安医科大学第二临床医学院皮肤科

出　　处：《中国皮肤性病学杂志》1998年第2期80-81,共2页The Chinese Journal of Dermatovenereology

摘　　要：为了提高对系统性硬皮病及皮肌炎的临床确诊率，通过ＥＮＡ抗原应用免疫印迹技术检测了１９例系统性硬皮病（ＳＳ）及２８例皮肌炎或多发性肌炎（ＤＭ／ＰＭ）患者抗Ｓｃｌ７０及抗Ｊｏ１抗体，并与系统性红斑狼疮（ＳＬＥ）、混合性结缔组织病（ＭＣＴＤ）共６２例及５０例健康人作了对照研究。结果表明：７０ＫＤ（抗Ｓｃｌ７０）多肽抗体是系统性硬皮病的特异性标记抗体，阳性率３１．６％；５５ＫＤ（抗Ｊｏ１）多肽抗体是皮肌炎的特异性标记抗体，阳性率４６．４％。ＳＬＥ、ＭＣＴＤ及健康人全部阴性。In order to improve the diagnosis of dermatomyositis and systemic scleroderma,antiScl70 and antiJo1 antibodies in sera from 19 cases of systemic scleroderma (SS) and 28 cases of dermatomyositis or polymyositits(DM/PM) were detected by immunoblotting technique using ENA antigen.62 cases of systemtic 1upus erythematosis (SLE) and mixed connective tissue diseases (MCTD) and 50 cases of healthy people were taken as control.The results indicated that 70KD polypeptide antibody(AntiScl70)was the specific antibody of systemic scleroderma,with a positive rate of 31.6%;55KD polypeptide antibody(antiJo1) was the specific antibody of dermatomyositis,with a positive rate of 46.4%.No antiScl70 and antiJo1 were detectable in patients with SLE and MCTD,nor in healthy people.The detection of antiScl70 and Jo1 is helpful for the differential diagnosis of systemic scleroderma and dermatomyositis.

关 键 词：免疫印迹 抗体 系统性硬皮病 皮肌炎 

分 类 号：R593.250.3[医药卫生—内科学]