α_1受体在应激性溃疡中作用的实验研究  

Experimental study on the role of α_1-adrenoceptor in stress ulcer

作　　者：李晓强[1] 杨乃众[2] 李占文[2] 杜如昱[2] 

机构地区：[1]华北煤炭医学院附属医院外科,063000 [2]北京医科大学第二临床医学,北京100044

出　　处：《中国危重病急救医学》1998年第3期140-142,共3页Chinese Critical Care Medicine

基　　金：北京医科大学硕士研究生课题

摘　　要：目的：探讨a1受体在应激性溃疡发病机制中的作用。方法：用放射自显影术显示胃粘膜下动脉a1受体，用激光多普勒血流仪测定胃粘膜血流。结果：胃体部粘膜下动脉的a1受体分布密度（617.7士39.9）明显高于胃窦部（474.4士22.7），P＜0．o1。应激时给予小剂量a受体阻断剂能明显改善胃粘膜血流（P＜0.001和P＜0．01），使胃粘膜损伤减轻（P＜0．001）。结论：交感-肾上腺素系统对胃体部粘膜血流作用大于胃窦部，可能是应激性溃疡好发于胃体部的一个重要原因；小剂量a受体阻断剂能够预防和治疗应激性溃疡。Objective: To study the role of a1 - adrenoceptor in the pathogenesis of stress ulcer.Methods:The distribution density of al --adrenoceptor and gastric mucosal blood flow (GMBF) were determined by autoradiography and laser Doppler blood flowmeter,respectively. Results: The distributiondensity of a1 - adrenoceptor were significantly higher in the corpus than in the antrum (617. 7± 39. 9 vs.474. 4 ± 22. 7,P<0' 01 ). Treatment with a low dose of a -adrenoceptor antagonist during stress,GMBFvalues were markedly improved(P＜0. 001 and P<0. 01 ) and mucosal damage was obviously ameliorated (P<0. 001 ). Conclusions:The influence of sympathetic system on GMBF is more pronounced in thecorpus than in the antrum,which may be a major reason for the common occurrence of stress ulcer inthe corpus. Additionally,treatment with a low dose of a - adrenoceptor antagonist can provide preventive or therapeutic effects on stress ulcer.

关 键 词：应激性溃疡 Α1受体 胃粘膜血流 放射自显影术 

分 类 号：R573.105[医药卫生—消化系统]