^(90)钇玻璃微球局部给药治疗肝癌的试验研究  

Experiment Study of Locally Injected90Y Glass Microsphere in the Treatment of Hepatoma

作　　者：李飞 杨浩 卓忠雄[1,2] 

机构地区：[1]解放军第二五四医院超声室 [2]第三军医大学新桥医院超声科

出　　处：《中华超声影像学杂志》1998年第2期119-121,共3页Chinese Journal of Ultrasonography

摘　　要：以８０只小鼠移植肝癌为模型，对其随机分为对照组及５个不同剂量的治疗组。对治疗组瘤内注射９０Ｙ玻璃微球（９０ＹＧＭ），以观察疗效，探寻有效治疗剂量。结果表明当瘤内给予１～３ｍｃｉ／ｃｍ３剂量的９０Ｙ时，肿瘤坏死或严重变性而无明显副作用。术后５天测定的肿瘤重量治疗组与对比组间差异显著（Ｐ值＜０．００１）；而治疗组间比较则无显著差异（Ｐ值＞０．０５）。Liver tumor cells were transplanted into eighty mice which were randomly divided into six groups as models. One group was kept as control while the other five groups received injections of different doses of 90\ Y glass microspheres directly into the center of the trmor to observe the effective dose of treatment . The results showed that when the dose was given at 1￣3 mci/cm3 there were nocrosis or serious degeneration of the tumor and no apparent side effect 5 days after injection. There was significant difference in weight of tumor between the the treated groups and the control group (P<0.001), but no significant difference existed between the treated groups (P>0.05). 

关 键 词：小鼠 肝癌模型 坏死 钇90 玻璃微球 治疗 

分 类 号：R735.705[医药卫生—肿瘤]