肝炎平对急性肝损伤大鼠细胞因子的影响  

Effect of Ganyanping on Cytokines in Acute Liver Injury Induced by D-GalN in Rats

作　　者：杜荔菁[1] 唐望先[1] 张文英[1] 李绍白[1] 

机构地区：[1]同济医科大学附属同济医院肝病研究所,武汉430030

出　　处：《中西医结合肝病杂志》1998年第1期28-30,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨中药肝炎平对急性肝损害的防护作用。方法:用D-氮基半乳糖(D-GalN)制各大鼠急性肝损伤模型,检测血清丙氨酸转氮酶活性(ALT)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)和白细胞介素8(IL-8)浓度的变化。结果:肝损伤组ALT活性为2442.2±445.1nmol/L,TNF-α浓度为8.07±1.93ng/L,IL-6浓度为2.56±0.87ng/ml,IL-8浓度为5.78±2.12ng/ml;肝炎平组分别为1258.6±468.4nmol/L、0.63±0.27ng/L、0.52±0.13ng/ml、1.28±0.72ng/ml,各细胞因子水平均较肝损伤组明显降低(P<<0.01)。结论:肝炎平可通过对免疫机制的调节,而降低TNF-α、IL-6和IL-8等细胞因子的生成和释放。Aim: To study the effect of Ganyanping (GYP) on acute liver injury in rats induced by D-galactosamime (D-GalN). Methods: Rat acute liver injury model was induced by D-galac-tosamine. Serum alanine transaminase (ALT), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) were detected. Results: the levels of ALT, TNF-α, IL-6 and IL-8 in D-GalN group were 2442. 2±445. Inmol/L, 8. 07±1. 93ng/L, 2. 56±0. 87ng/ml and 5. 78±2.12ng/ml respectively, whereas in GYP group they were 1258. 6±468.4nmo1/L> 0. 63±0. 27ng/ L, 0. 52±0. 13ng/ml and 1. 28±0. 72ng/ml respectively. The levels of ALT, TNF-α, IL-6 and IL-8 were markedly decreased in GYP group compared with D-GalN group (P<0. 01). Conclusion: GYP could modulate the immune defence and inhibit the production of some cytokines including TNF-α, IL-6 and IL-8 etc. It has a significant protective effect on liver cells.

关 键 词：肝炎平 肝损害 大鼠 细胞因子 

分 类 号：R575.105[医药卫生—消化系统]