PCNA、VEGF在甲状腺乳头状癌中的表达及意义  

Expression and clinical significance of PCNA and VEGF in thyroid papillary carcinoma

作　　者：瓮生彬[1] 张建波[1] 郑超[1] 杨永丰[1] 张淑艳[1] 徐德龙[2] 

机构地区：[1]河北大学附属医院急诊外科,河北保定071000 [2]河北医科大学附属三院普外科,河北石家庄050051

出　　处：《同济大学学报（医学版）》2009年第2期75-77,共3页Journal of Tongji University(Medical Science)

摘　　要：目的探讨PCNA、VEGF在甲状腺乳头状癌等组织中的表达及临床意义。方法用免疫组化S-P法,检测30例甲状腺乳头状癌、30例甲状腺滤泡状腺瘤和30例癌旁正常甲状腺组织中PCNA、VEGF表达。结果PCNA、VEGF在甲状腺乳头状癌中的表达率显著高于甲状腺滤泡状腺瘤及癌旁正常甲状腺组织(P<0.01)。且两者在甲状腺乳头状癌中表达率呈正相关。结论PCNA、VEGF表达可作为甲状腺癌的协助诊断指标,对临床治疗和预后判断具有重要的指导意义。Objective To study the expression and clinical significance of proliferating cell nuclear antigen（PCNA） and vascular endothelial growth factor（VEGF）in thyroid papillary carcinoma.Methods Expression of PCNA and VEGF in 30 thyroid papillary carcinoma cases,30 thyroid follicular adenoma and 30 adjacent normal tissues were detected by using immunohistochemical staining technique（S-P method）.Results The positive rates of PCNA and VEGF in thyroid papillary carcinoma were significantly higher than those in thyroid follicular adenoma and the normal thyroid tissues（P〈0.01）.PCNA and VEGF were positively correlated in thyroid papillary carcinoma.Conclusion The expression of PCNA and VEGF could be the diagnostic indexes of papillary thyroid carcinoma and also had guiding significance for clinical treatment and patients＇ prognosis.

关 键 词：甲状腺乳头状肿瘤 增殖性细胞核抗原 血管内皮生长因子 免疫组化S-P染色 甲状腺滤泡状腺瘤 

分 类 号：R736.1[医药卫生—肿瘤]