成人Still病108例肝脏损害分析  

Liver diseases in adult-onset Still＇s disease

作　　者：刘建忠[1] 刘艳芳[1] 张广兰[1] 王小磊[1] 谭举朋[1] 韩明[1] 

机构地区：[1]山东省潍坊市益都中心医院风湿免疫科,262500

出　　处：《中华全科医师杂志》2009年第5期337-339,共3页Chinese Journal of General Practitioners

摘　　要：分析108例成人Still病患者的临床资料。结果示108例中56例合并肝脏损害，发生率为51．9％，其性别、年龄、从发病到确诊时间以及发热、皮疹、关节炎、淋巴结肿大、贫血等临床表现及实验室检查指标与不伴肝脏损害患者比较差异均无统计学意义（均P〉0．05）。肝损害临床症状不典型，患者中8例有消化道症状。56例肝功能异常，其中ALT和AST升高最明显。B超检查肝脏肿大24例。提示成人Still病合并肝损害并不少见，可能与疾病本身和药物有关。患者对激素治疗敏感，预后较好。Clinical data of 108 patients with adult-onset Still＇s disease （AOSD） were analyzed. The results showed that 56 patients （ 51.9% ） developed liver damage and abnormal liver function （ alanine aminortransferase and aspartate aminortransferase were significantly increased）. Gender, age, time from disease onset to confirmed diagnosis, fever, rash, arthritis, pharyngeal pain, splenomegaly, lymphadenopathy, anemia, leukocvtosis, thrmbocytosis, and increased erythrocyte sedimentation rate, serum C-reactive protein, and serum iron protein showed no significant difference between the two groups （ P 〉 0.05）. Clinical symptoms of liver damage were atypical. Among the 56 patients with liver damage, 8 were presented with gastrointestinal symptoms, and 24 showed enlarged liver in B-ultrasound examination. Our results suggest the prevalence of liver damage in AOSD patients may be high, which could attribute to the disease itself and the medication. The patients would expect good response to corticosteroid treatment and satisfactory outcomes.

关 键 词：STILL病 成年型 肝疾病 

分 类 号：R575[医药卫生—消化系统]