帕金森病立体定向丘脑腹外侧核射频毁损手术疗效分析  

Curative Effect Analysis of Stereotatic Posterventral Lateral Radiofrequency Thalamotomy in Treating Patients with Parkinson's Disease

作　　者：曾凡俊[1] 夏勋[1] 邢学民[1] 匡永勤[1] 陈林[1] 贺伟琪 杨涛[1] 林龙[1] 

机构地区：[1]成都军区总医院脑外科,四川成都610083

出　　处：《西南军医》2009年第3期391-392,共2页Journal of Military Surgeon in Southwest China

摘　　要：目的探讨影响帕金森病立体定向丘脑腹外侧核射频毁损手术的疗效因素。方法分析20多年来我院采用立体定向手术治疗帕金森病的影像学改变及影响疗效的因素。结果本组病例症状完全控制950例(74.21%),症状控制伴有肢体麻木、发音、情感、智能障碍270例(21.09%)。无效50例(3.9%),恶化10例(0.78%)。结论CT及MR I靶点定位法与脑室造影定位法无显著差异,而靶点定位、毁损范围与手术疗效及并发症密切相关。Objective To discuss the factors related to the curative effect of stereotatic posterventral lateral radiofrenquency thalamotomy in treating patients with Parkinson＇s disease （ PD ）. Methods An analysis was made to the images of the patients treated by stereotatic surgery in the past 20 years and the factors related to the curative effect. Results Out of the 1280 cases in the study,950 cases（74. 21% ） showed total control of symptoms,270 cases （21.09%） had certain control of symptoms but still with limb numbness,dysphonia, affective disorder and intelligence impairment ;50 cases （3.9% ） were of no effect, and 10 cases （0. 78% ）were deteriorated. Conclusions There exists no significant difference between CT or MRI localization and ventrictdography localization while the target localization and the size of lesion are closely related to the curative effect and the occurrence of complicatins.

关 键 词：帕金森病 立体定向外科 丘脑毁损术 

分 类 号：R742.5[医药卫生—神经病学与精神病学]