PTTG与c-myc在食管癌中的表达及其相关性  

Expression and Correlation of PTTG and c-myc in Esophageal Carcinoma

作　　者：林称意[1] 郭家龙[1] 左顺庆[1] 张军[1] 谢斌生[1] 

机构地区：[1]郧阳医学院附属太和医院胸心外科,湖北十堰442000

出　　处：《肿瘤防治研究》2009年第5期415-418,共4页Cancer Research on Prevention and Treatment

基　　金：湖北省科技攻关资助项目(2004AA301C97)

摘　　要：目的探讨食管鳞癌组织中垂体肿瘤转化基因(PTTG)和原癌基因(c-myc)的表达和相关性。方法采用免疫组织化学SP法检测PTTG和c-myc在食管癌组织和癌旁正常食管组织中的表达情况。结果48例食管癌组织中PTTG和c-myc的阳性表达率分别为72.9%(35/48)和67.7%(32/48),显著高于癌旁正常食管组织中的表达(分别为10.4%和14.6%,P<0.05),PTTG和c-myc的表达与有无淋巴结转移、TNM分期显著相关(P<0.05),与患者年龄、性别、瘤体大小和肿瘤组织分化程度无相关性;PTTG和c-myc的表达呈正相关(P<0.05)。结论PTTG和c-myc蛋白在食管癌中具有高表达,两者可能参与了食管癌的发生,在食管癌的侵袭和转移中发挥重要作用,并且具有协同作用。Objective To study the expression of PTTG and c-myc in esophageal squamous carcinoma and correlation with clinic pathological features. Methods Immunohistochemical SP method was used to detect the expression of PTTG and c-myc proteins in 48 esophageal carcinoma tissues and para-cancerous tissues. Results The positive rates of PTTG and c-myc in esophageal carcinoma tissues were 72. 9% （35/48）and 67. 7%（32/48）respectively, which were significantly higher than that in para-cancerous tissues （10. 4% and 14. 6%, P〈0. 05）. The positive expression of PTTG and c-myc was correlated with lymph node metastasis and TNM staging. There was no relationship with age, gender, tumor size and histological grades, respectively. At the same time, the expression of PTTG and c-myc was positive correlation （P〈0. 05）. Conclusion PTTG and c-myc are over-expressed in esophageal carcinoma. They may play a cooperative role in development, in invision and metastasis of esophageal carcinoma.

关 键 词：食管肿瘤 免疫组织化学 垂体肿瘤转化基因 C-MYC 

分 类 号：R735.1[医药卫生—肿瘤]