快速老化小鼠SAMP8研究进展  

Progress in studies on senescence accelerated mouse prone 8(SAMP8)

作　　者：周伟勤[1] 毕明刚[1,2] 杜冠华[2] 

机构地区：[1]中国医学科学院药用植物研究所,北京100093 [2]中国医学科学院药物研究所,北京100050

出　　处：《中国药理学通报》2009年第5期565-568,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30772750)

摘　　要：快速老化小鼠SAMP8(senescence-accelerated mouseprone/8)是一个从普通的遗传群AKR/J系小鼠中通过表型选择培育出的快速老化小鼠,表现为早期增龄性学习记忆缺陷,同时伴有Aβ淀粉样蛋白沉积,是目前公认的有效的研究阿尔采末病(Alzheimer’s disease,AD)动物模型。同属SAMR1表现为抗快速老化,具有正常的老化特性,常用作正常对照。目前SAMP8已被广泛应用于研究快速学习记忆缺陷的发病机制,以及评价抗衰老及改善学习记忆功能的药物等。The senescence accelerated mouse prone 8 strain was developed through phenotypic selection from a common genetic pool of AKR/J strain of mice. The SAMP8 strain exhibits agerelated deterioration in memory and learning as well as AI3 accumulation early in its lifespan, and it is considered as an effective model for studying Alzheimer＇s disease （AD）. The SAMR1 strain （senescence accelerated resistant） is control, which exhibits normal aging characteristics. The present studies of SAMP8 have focused on revealing mechanism of accelerated deficits in learning and memory, and evaluating the efficiency of therapeutic drugs against AD.

关 键 词：快速老化小鼠 阿尔采末病 动物模型 

分 类 号：R-05[医药卫生] R338.64