乳腺癌中nm23-H1蛋白表达及临床病理意义的探讨  

RESEARCHES ON nm23-Hl PROTEIN EXPRESS AND THEIR CLINICAL AND PATHOLOGICAL SIGNIFI-CANCE

作　　者：路向前[1] 陈同钰[2] 袁晓璞[2] 

机构地区：[1]常州市第一人民医院,常州213003 [2]苏州医学院附属三院

出　　处：《中国癌症杂志》1998年第1期40-42,共3页China Oncology

摘　　要：目的 为了探讨乳腺癌病人nm23-Hl蛋白表达与临床预后的关系及意义.方法 采用免疫组化ABC法,对87例原发性乳腺癌手术标本经福尔马林固定、石蜡包埋组织进行nm23-H1蛋白表达的测定.结果乳腺癌原发灶中nm23-Hl表达阳性率为51.72%,区域淋巴结转移组阳性率为26%,无淋巴结转移组阳性率86.49%,差异具有显著性意义(P<0.001).随着乳腺癌核分裂的增多及病理学分级的增高,nm23-H1表达率下降.nm23-H1表达在生存期大于/等于5年及小于5年间及有无复发,脏器转移间差异显著(P<0.001).结论测定乳腺癌组织中nm23-H1表达,对判断转移和预后都有积极的临床意义.PURPOSETo study the relation and meanings of nm23-Hl protein expression and prognosis of breast cancer patients. METHODS The determines of nm23-Hl protein express in formalin fastened and paraffin wax packing and merging organ of 87 primary breast cancer operation. Sample were studied with histochemical ABC technics. RESULTS The results show that nm23-Hl positive rate of breast cancer primary tumor the group of regional lymphatic metastasis and lymphatic metastasis was 51. 72%, 26%, 86. 49% respectively. The differences have significant sense (P<0. 001). With the increase of breast cancer nuclear fission and pathological grades, the express rate of nm23-Hl fell down. The differences of nm23-Hl were significant among more than or equal to five years, less than five years and recur or no. CONCLUSION To measure the express of nm23-Hl in breast cancer organs have great positive sense to judge cancer transfer and prognosis.

关 键 词：乳腺癌 预后 NM23-H1基因 基因表达 

分 类 号：R737.902[医药卫生—肿瘤]