热休克蛋白27在肺癌中的表达及其临床意义  

Expressions of HSP27 in lung carcinoma and its clinical implication

作　　者：赵勇刚[1] 谢伟[1] 冯茂辉[1] 余佳莉[1] 段丽[1] 吴红艳[1] 谢辉[1] 

机构地区：[1]武汉大学中南医院肿瘤外科,湖北武汉430071

出　　处：《中国现代医学杂志》2009年第8期1192-1194,共3页China Journal of Modern Medicine

基　　金：湖北省自然科学基金资助项目(No:2004ABA159);湖北省科技攻关资助项目(No:2003AA301C01;2005AA304B05);武汉市科技攻关重点项目(No:200860423230)

摘　　要：目的通过观察肺癌中热休克蛋白27(HSP27)的表达,探讨HSP27表达与肺癌增殖和转移的关系,并分析其意义。方法采用免疫组织化学SP法检测63例肺癌组织、21例肺良性病变、22例正常肺组织标本中HSP27蛋白的表达水平,分析其与肺癌临床病理因素之间关系。结果HSP27蛋白的阳性表达主要定位在细胞质内,少数也可见胞膜着色。HSP27蛋白在肺良性肿瘤及正常肝组织中未见表达,而在恶性肿瘤中的阳性表达率为63.5%(40/63),与前两者相比差异有显著性(P<0.05)。HSP27的表达与肺癌的临床转移、细胞的分化程度相关,而与年龄和肿瘤的大小无明显相关性。结论HSP27在肺癌组织中有广泛表达,HSP27在临床有转移和病理细胞分化低的组织中表达增高,HSP27与肺癌的发生、恶性程度及转移有关,在肺癌的预后判断中具有重要意义。[Objective] To determine the expression of HSP27 （heat shock protein 27, a member of heat shock protein family） in lung carcinoma and investigate the relationship between HSP27 expression and invasion of lung carcinoma. [Methods] Immunohistochemieal staining was used to detect the expression of HSP27 in 63 cases of lung carcinoma, 21 cases of benign tumor and 22 cases of normal lung tissue to analyze the relationship between their expression and various clinic pathologic factors of lung carcinoma. [Results] None of the normal intestinal tissues and benign tumor were HSP27 positive. In 63 lung carcinoma specimens, the positive expression rate of HSP27 was 63.5% （40/63）. HSP27 expression correlated with the degree of tumor differentiation and tumor metastasis （P 〈 0.05）. But not related to some clinic pathological characteristics such as the age, sex and size. [Conclusions] The expression of HSP27 in tumor tissue may be a new marker of the biological behavior of lung carcinoma.

关 键 词：肺肿瘤 热休克蛋白 免疫组织化学 转移 

分 类 号：R734.2[医药卫生—肿瘤]