谷氨酰胺联合洛派丁胺治疗化疗相关性腹泻的临床研究  

Study on the therapeutic of glutamine and loperamide for chemotherapy-induced diarrhea in the patient with digestive tract carcinoma

作　　者：张贵堂[1] 成丽梅[1] 马利辉[1] 张静[1] 贾如江[1] 

机构地区：[1]河北省邯郸市中心医院普二科,056001

出　　处：《中国现代药物应用》2009年第10期6-7,共2页Chinese Journal of Modern Drug Application

摘　　要：目的研究谷氨酰胺联合洛派丁胺治疗化疗相关腹泻的临床效果。方法将128例化疗期间出现化疗相关性腹泻的患者随机分为治疗组65例和对照组63例。治疗组给于谷氨酰胺颗粒3.0g/d,并口服洛派丁胺,首次4 mg,其后每4 h口服2 mg,5 d为一个疗程。对照组口服思密达成人每日3次,每次3 g。72 h后观察疗效。结果治疗组显效率及总有效率明显优于对照组(P<0.05)。结论谷氨酰胺联合洛派丁胺治疗化疗相关性腹泻疗效显著。Objective To study the efficacy of Glutamine and Loperamide for chemotherapy-induced diarrhea in the patient with digestive tract carcinoma. Methods One hundred and twenty eight persons with chemotherapy-induced diarrhea were divided into treatment group and control group randomly, treatment group take glutamine 3 g once daily and loperamide 4 mg at the first time and then 2 mg each four hours orally and treat a distances for five days. Control group take smeeta 3 g thrice daily orally. Each patient was observed the change after 72 h. Results Treatment group has better efficacy in the treatment of chemotherapy-induced diarrhea than that of control group. Conclusion It was significantly efficacy that Glutamine and Loperamidc for chemotherapy-induced diarrhea in the patient with digestive tract carcinoma.

关 键 词：化疗性相关性腹泻 谷氨酰胺 洛派丁胺 思密达 

分 类 号：R730.5[医药卫生—肿瘤]