奥沙利铂联合亚叶酸钙/氟尿嘧啶治疗晚期胃癌的临床观察  

Oxaliplatin combined with leucovorin and 5-fluorouracil chemotherapy in treatment of advanced gastric cancer

作　　者：徐金发[1] 潘明[1] 鲍瑜[1] 陈倩[1] 

机构地区：[1]安徽省池州市人民医院肿瘤内科,247000

出　　处：《蚌埠医学院学报》2009年第5期417-419,共3页Journal of Bengbu Medical College

摘　　要：目的：观察奥沙利铂（L-OHP）联合亚叶酸钙（LV）、氟尿嘧啶（5-Fu）治疗晚期胃癌的近期疗效和毒副作用。方法：35例均接受L-OHP200mg静脉滴注，第1天；LV200mg／m^2静脉滴注30min，然后给予5-Fu200mg／m^2静脉推注，后续5-Fu400mg／m^2静脉滴注，第1～5天，4周重复，至少治疗2周期后判定疗效。结果：可评价疗效者34例，完全缓解2例，部分缓解14例，总有效率47．1％。可评价毒性患者34例，胃肠道反应为最主要毒副作用，其次为骨髓抑制白细胞减少、周围神经毒性。结论：L-OHP联合LV、5-Fu治疗晚期胃癌疗效较好，不良反应较轻能耐受，是晚期胃癌可供选择方案。Objective：To explore the effects and side effects of oxaliplatin（L-OHP） combined with leucovorin （LV） and 5-fluorouracil （5-Fu） regimen on patients with advanced gastric cancer. Methods ：Thirty-five patients with advanced gastric cancer were administered oxaliplatin 200 mg intravenously at day 1. LV 200 mg/m2 was infused intravenously for 1/2 hour, then 5-Fu 200 mg/m2 bolus was given,followed by 400 mg/m2 intravenous drip. The therapy lasted from day 1 - 5, and then repeated every 4 weeks. The results were evaluated after 2 cycles. Results：Of the thirty-five patients,complete response was observed in two cases and partial response in 14. The overall response rate achieved 47. 1%. The main side effects were nausea, vomiting, myelosuppression and peripheral neurotoxicity. Conclusions：Oxaliplatin combined with LV/5-Fu is highly effective and well tolerable. It is a selective regimen for patients with advanced gastric cancer.

关 键 词：胃肿瘤 肿瘤/药物疗法 联合 奥沙利铂 亚叶酸钙 氟尿嘧啶 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]