乳腺癌雌孕激素受体表达与病理分型、患者年龄、月经状态关系的研究  

Research of relationship between expression of estrogen and progestogen receptors and pathologial types,patients ages,menstrual states in breast cancer

作　　者：王银萍[1] 刘铮[1] 张元德[1] 张俊格[1] 

机构地区：[1]白求恩医科大学第一临床学院病理科

出　　处：《中国实验诊断学》1998年第2期78-79,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：探讨雌、孕激素受体（ＥＲ、ＰＲ）与病理分型、患者年龄及月经状态的关系。方法应用免疫组织化学方法对１１６例石蜡包埋的乳腺癌（ＢＣ）组织进行ＥＲ、ＰＲ检测。结果ＥＲ和ＰＲ的表达率分别为６９．０％和６１．２％，病理分型恶性程度越高，患者年龄越轻，ＥＲ（ＰＲ）表达率越低。结论ＥＲ、ＰＲ在ＢＣ中有较高的表达率，ＥＲ、ＰＲ测定对指导ＢＣ患者采用内分泌化疗药物具有重要作用。Objective To discuss the relationship between estrogen and progestogen receptors(ER,PR) and patological types,metastasis of lymph nodes,patient ages,menstrual states.Methods The investigation was to determine the expression of ER,PR of paraffin embedded tissues of breast cancer(BC) in 116 cases by immunochemical method.Results The results showed that the expression rate of ER and PR was 690% and 612% respectively,and that of ER and PR was identical.The higher the matignant diffayenllation of tumor and the younger the patient,the tower the expression rate of ER.Conclusion The results showed that there is higher expression rate of ER,PR in BC and the determination of ER,PR plays an important role in conducting endocrine anticancer drug treatment to patients with BC.

关 键 词：孕激素 受体 乳腺癌 病理分型 雌激素 

分 类 号：R737.902[医药卫生—肿瘤]