程序性细胞死亡因子10在胃癌组织中的表达及其临床病理学意义  

Expression of programmed cell death factor 10 protein and its clinicopathological significance in gastric cancer

作　　者：朱晓妍[1] 王德荣[2] 曲飞[3] 

机构地区：[1]山东大学医学院,济南250012 [2]山东大学附属济南市中心医院消化内科,济南250013 [3]山东大学附属济南市中心医院病理科,济南250013

出　　处：《山东大学学报（医学版）》2009年第5期92-94,98,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨在胃癌发生过程中凋亡相关基因程序性细胞死亡因子10(programmed cell death factor 10,PDCD10)的表达及其临床病理学意义。方法采用SP免疫组织化学方法检测26例正常胃粘膜,22例慢性萎缩性胃炎伴肠上皮化生及66例胃癌组织标本中PDCD10基因的表达,分析其与临床病理学参数之间的关系。结果正常胃粘膜、萎缩性胃炎伴肠上皮化生及胃癌组织中PDCD10表达阳性率分别为11.5%、31.8%和63.6%,呈现上调趋势。相关分析表明,PDCD10的表达上调与肿瘤分化程度及转移密切相关(P<0.05),而与性别、年龄及肿瘤生长部位无关(P>0.05)。结论胃癌组织中PDCD10表达较正常胃粘膜、萎缩性胃炎伴肠上皮化生明显上调,其表达程度与胃癌的分化程度及侵袭转移相关。Objective To investigate expression of programmed cell death factor 10 （PDCDIO） protein and its clinicopathological significance in the progress of gastric cancer. Methods Expression of PDCD10 was determined by the SP immunohistochemical method in 26 cases of normal gastric mucosa, 22 cases of chronic atrophic gastritis with intestinal metaplasia and 66 cases of gas- tric carcinoma. Relationship between expression of PDCD10 and clinicopathological characters of gastric carcinoma was analyzed. Results The positive rates of expression in normal gastric mucosa, chronic atrophic gastritis with intestinal metaplasia and gastric carcinoma were l1.5%, 31.8% and 63.6% respectively, which was progressively up-regulated. In gastric cancer, expression was not related to sex, age, and site of tumors （ P 〉 0.05）, in contrast, positive rates were related to the degree of differentiation clinical stages, lymph nodes and distant metastases （ P 〈 0.05）. Conclusion PDCD10 expression in gastric cancer tissues is significantly higher than that in the normal gastric mucosa and chronic atrophic gastritis with intestinal metaplasia tissues. There is a correlation between expression of PDCD10 and histological grades and metastases of gastric cancer.

关 键 词：程序性细胞死亡因子10 胃肿瘤 细胞凋亡 

分 类 号：R735.2[医药卫生—肿瘤]