急性脑梗死患者早期血清中OX-LDL、HS-CRP含量水平与脑水肿严重程度的关系  

The Relationship of Serum OX-LD、LHS-CRP Level with Severity Degreeof Cerebral Edema on Patients with Acute Cerebral Infarction

作　　者：冯继贞[1] 沈小雯[1] 李新立[1] 唐淑花[1] 刘群才[1] 李强[1] 

机构地区：[1]中国人民解放军第159医院神经内科,河南驻马店463008

出　　处：《黑龙江医学》2009年第4期241-242,257,共3页Heilongjiang Medical Journal

摘　　要：目的探讨早期血清中氧化低密度脂蛋白(OX-LDL)、高敏C-反应蛋白(HS-CRP)不同含量水平与急性脑梗死(ACI)患者脑水肿严重程度的关系。方法采用酶联免疫吸附试验、微粒化增强免疫固定试验测定152例ACI者入院第2 d血清中OX-LDL、HS-CRP含量水平,并与30例健康人(对照组)作对照。同时观察入院第2 d血清中OX-LDL、HS-CRP不同含量水平者入院第1、3、5、7 d双侧大脑半球脑电阻抗扰动系数。结果ACI早期血清中OX-LDL、HS-CRP含量水平明显高于对照组(P<0.01);入院第2 d血清中OX-LDL、HS-CRP不同含量水平第1 d各组间患侧、健侧电阻抗扰动系数比较无明显差异(P>0.05),入院第3 d较第1 d患侧、健侧电阻抗扰动系数均明显升高(P<0.05,P<0.01),但OX-LDL、HS-CRP含量水平越高,患侧、健侧电阻抗扰动系数升高越明显(P<0.05);第7 d较第3 d患侧电阻抗扰动系数均明显降低(P<0.01),但OX-LDL、HS-CRP含量水平越低,患侧电阻抗扰动系数降低越明显(P<0.01)。结论ACI患者早期血清中OX-LDL、HS-CRP含量水平明显升高。其早期含量水平越高,脑水肿形成后越严重;含量水平越低,脑水肿形成后越轻,且消退越明显。Objective To explore the relationship of serum OX - LD, LHS - CRP level with severity degree of cerebral edema on patients with acute cerebral infarction.Methods With micronize strengthen immunofixation methods, the serum OX- LD,LHS- CRP level of 152 cases patients with ACI were measured on the second days after hospitalization, meanwhile, the turbulence coefficient of electric impedance of cerebral hemisphere were observed on patients on first, 3 th, 5 th and 7 th day after hospitalization. In addition, 30 cases healthy volunteers were supposed as control groups. Results The serum OX - LD, LHS- CRP level of patients with ACI were higher than control group （ P 〈 0.01）, there were no significant the turbulence coefficient of electric impedance of cerebral hemisphere in different serum OX - LD, LHS - CRP level of patients with ACI of observe and control group on the first days after hospitalization （ P 〉 0.05） ,but higher on the 3th day than on the first day（ P 〈 0.05, P 〈 0.01） ,the serum OX - LD,LHS - CRP level were higher, the turbulence coefficient were higher（ P 〈 0.05）, while the turbulence coefficient were lower on the 7 th days than on the 3 th days（ P 〈 0.01）.The serum OX- LD,LHS- CRP level were lower, the turbulence coeffi- cient were lower obviously（ P 〈 0.01 ）. Conclusion The serum OX - LD, LHS - CRP level of patients with ACI were higher than control group, The serum OX - LDL level were higher, severity degree of cerebral edema were higher, it were lower, severity degree of cerebral edema were lower.

关 键 词：急性脑梗死 脑水肿 血清氧化低密度脂蛋白 高敏C-反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.61[医药卫生—临床医学]