β-连环蛋白:卵巢癌治疗的新靶点  

β-Catenin Molecule: a New Target of Ovarian Cancer Therapy

作　　者：蒋翠莲[1] 胡卫华[1] 窦骏[1] 

机构地区：[1]东南大学基础医学院病原生物学与免疫学系,江苏南京210009

出　　处：《生物技术通讯》2009年第3期408-410,共3页Letters in Biotechnology

基　　金：国家自然科学基金(90406023)

摘　　要：卵巢癌是致死率最高的妇科肿瘤,早期不易发现。常规手术及放化疗均难以明显提高患者的远期生存率,因此寻求新的治疗方法迫在眉睫。β-连环蛋白(β-catenin)作为E-cadherin(E-钙调蛋白)/β-连环蛋白系统和Wnt信号通路中的关键分子,在多种肿瘤的发生、发展过程中起着重要作用。我们主要阐述了β-连环蛋白在各类卵巢癌中的表达情况及针对β-连环蛋白分子的一些靶向治疗手段。Ovarian cancer is the highest mortality in gynecological cancer and is hard to be detected in the early stage. Operation and radiotherapy or chemotherapy can hardly improve the long-term survival rate in patient with ovarian cancer. Thus it is urgent to find new therapeutics to increase recovery rate. As the key molecule of E-cadherin/β-catenin system and the Wnt signal pathway, β-catenin plays a vital role in the tumorigenesis and development in many tumors. The expression ofβ-catenin in various types of ovarian cancers and some targeted therapeutic tools aimed at β-catenin molecule were respectively discussed in this review.

关 键 词：卵巢癌 Β-连环蛋白 靶向治疗 

分 类 号：R730[医药卫生—肿瘤] Q25[医药卫生—临床医学]