E-cadherin/β-catenin与CD_(44)V_6在胃癌中的表达及意义  

The clinical significance of E-cadherin/β-catenin and CD_(44)V_6 expression in gastric carcinoma

作　　者：翁阳[1] 陈明净[1] 罗志飞[1] 黄幼生[1] 杨丞[1] 丁莉利[1] 徐海霞[2] 

机构地区：[1]海南医学院病理学教研室,海南海口571101 [2]海口市人民医院病理科,海南海口570208

出　　处：《海南医学院学报》2009年第6期531-534,537,共5页Journal of Hainan Medical University

基　　金：海南省自然科学基金资助项目(30521)~~

摘　　要：目的:探讨胃癌组织中E-钙黏连蛋白(E-cadherin,E-cad)和β-连接素(β-catenin,β-cat)及CD44V6的表达及其与胃癌发生发展,肿瘤分化、浸润和转移的关系。方法:采用免疫组织化学(S-P)法检测70例胃癌、30例癌旁组织、25例慢性萎缩性胃炎和28例胃正常组织中E-cad、β-cat和CD44V6的表达。结果:胃癌组织中E-cad和β-cat的表达明显低于慢性萎缩性胃炎、癌旁组织和正常胃黏膜,E-cad的阳性表达率与胃癌的浸润深度、淋巴结转移密切相关,与分化程度无关。β-cat阳性表达与胃癌的分化程度、浸润深度密切相关,与淋巴结转移无关。胃癌组织中CD44V6蛋白的阳性表达率明显高于慢性萎缩性胃炎、癌旁组织和正常胃黏膜组织,并与胃癌的浸润深度和淋巴结转移密切相关,与分化程度无关。结论:E-cad、β-cat及CD44V6的表达分别与胃癌的分化、浸润和转移密切相关,同时检测E-cad、β-cat及CD44V6的表达可作为判断胃癌浸润、转移及预后的良好参考指标。Objective： To explore the expression and clinical significance of E-cadherin, β-catenin and CD44 V6 in occurrence, development, metastasis and differentiation of gastric carcinoma. Methods： Immunohisto- chemical staining for E-cadherin, β-catenin and CD44V6 were performed to test biopsy specimens of human gastric tissues, including gastric carcinoma （70 cases）, para-cancer tissue （30 cases）, chronic atrophic gastritis tissues （25 cases） and normal gastric tissues （28 cases）. Results： Immunohistochemical study showed that E-cadherin, β-catenin and CD44V6 were expressed in gastric cancer tissues with positive rate of 60.0% , 68.6% and 71.4%, respectively. E-cadherin expression was significantly correlated with lymph node metastasis and invasion. β-catenin expression was associated with tumor differentiation and invasion. CD44V6 was associated with tumor lymphnode metastasis and invasion. Conclusion： E-cadherin, β-catenin and CD44V6 expression are associated with invasion, metastasis and differentiation of gastric carcinoma, which are important factors for judging invasion metastasis and differentiation of gastric carcinoma.

关 键 词：胃 癌 E-钙黏连蛋白 Β-连接素 CD44V6 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]