IL-1和TGF-β_1在膝骨关节炎滑膜中的表达及意义  

Expression and significance of IL-1 an TGF-β_1 in the membranae synovialis of osteoarthritis

作　　者：张志刚[1] 曹靖[1] 陈德生[1] 张德新[1] 贾宝明[1] 孙义忠[1] 

机构地区：[1]华北煤炭医学院附属骨科医院,河北唐山063000

出　　处：《山东医药》2009年第19期7-9,共3页Shandong Medical Journal

摘　　要：目的进一步探讨膝骨关节炎(OA)的发生机制。方法选择80例OA患者的关节滑膜标本,连续性组织切片;同法选择20例非正常死亡及外伤性截肢的青年滑膜组织作为对照组。两组采用免疫组化方法检测TGF-β1和IL-1在滑膜组织中的表达情况,双盲法计数阳性表达率。结果IL-1、TGF-β1蛋白在OA滑膜组织中的表达增加,且二者表达随着OA病情加重而增强。结论IL-1、TGF-β1可能参与了OA滑膜的病理过程,对滑膜炎症分别起促进和抑制作用。Objective To investigate the pathogenesis of osteoarthritis （OA） . Methods The synovial membrane specimen from 80 patients with knee joint OA （ OA group） and 20 patients with abnormal dead or traumatic amputation and discoid meniscus young people（ control group）were selected. Expression of IL-1 an TGF-β1 in two groups were detected by using immunohistochemical method,and the positive rates were counted. Results The expressions of TGF-β1 and IL-1 in OA group were significandy higher than that in the control group , and both showed positive correlation with severity of OA. Conclusions TGF-β1 and IL-1 may participate in the pathologic process of OA, possible mechanism maybe inhibit and improve the inflammatory reaction of membranae synovialis.

关 键 词：骨关节炎 白介素-1 转化生长因子-Β1 

分 类 号：R737.14[医药卫生—肿瘤] R684.3[医药卫生—临床医学]